Assessment of normal flow patterns in the pulmonary circulation by using 4D magnetic resonance velocity mapping
Assessment of normal flow patterns in the pulmonary circulation by using 4D magnetic resonance velocity mapping
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DOI：
10.1016/j.mri.2012.06.036
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发表时间：
2013-02-01
影响因子：
2.5
通讯作者：
Uribe, Sergio
中科院分区：
文献类型：
--
作者：
Baechler, Pablo;Pinochet, Natalia;Uribe, Sergio
目的：本研究的目的是分析流动模式在肺循环的健康志愿者通过使用4D流动磁共振imaging材料和方法：这项研究是由当地的伦理委员会批准，所有受试者提供书面知情同意书18名志愿者进行了4D流动扫描的整个心脏。还纳入了2例先天性心脏病患者，以检测可能的血流异常模式（患者1：矫正型大动脉转位（TGA）;患者2：部分肺静脉回流异常和房间隔缺损）。为了分析血流模式，将2D平面放置在主肺动脉（PA）、左PA和右PA上。流动模式进行了评估手动由两个独立的观众使用矢量场，流线和粒子的痕迹，半自动涡quantification.Results：两个反向旋转的螺旋被发现在志愿者的主要PA。在15名志愿者的右PA中检测到右旋螺旋流。通过颗粒痕迹分析螺旋流显示，两个螺旋主要贡献于右PA中的流动。在校正TGA的患者中，未检测到螺旋流。异常涡流可视化在主PA的患者2，表明平均PA pressure.Conclusions：螺旋流是正常存在于主PA和右PA。4D血流是无创评估肺循环中复杂血流模式的绝佳工具。了解正常和异常的血流模式可能有助于评估先天性心脏病患者，增加其他成像方式无法检测到的功能信息。(C)2013 Elsevier Inc. All rights reserved.
Objective: The purpose of this study was to analyze flow patterns in the pulmonary circulation of healthy volunteers by using 4D flow magnetic resonance imaging.Materials and Methods: The study was approved by the local ethics committee and all subjects gave written informed consent Eighteen volunteers underwent a 4D flow scan of the whole-heart. Two patients with congenital heart disease were also included to detect possible patterns of flow abnormalities (Patient 1: corrected transposition of great arteries (TGA); Patient 2: partial anomalous pulmonary venous return and atrial septal defect). To analyze flow patterns, 2D planes were placed on the main pulmonary artery (PA), left and right PA. Flow patterns were assessed manually by two independent viewers using vector fields, streamlines and particle traces, and semi-automatically by vorticity quantification.Results: Two counter-rotating helices were found in the main PA of volunteers. Right-handed helical flow was detected in the right PA of 15 volunteers. Analysis of the helical flow by particles traces revealed that both helices contributed mainly to the flow in the right PA. In the patient with corrected TGA helical flow was not detected. Abnormal vortical flow was visualized in the main PA of patient 2, suggesting elevated mean PA pressure.Conclusions: Helical flow is normally present in the main PA and right PA. 4D flow is an excellent tool to evaluate noninvasively complex blood flow patterns in the pulmonary circulation. Knowledge of normal and abnormal flow patterns might help to evaluate patients with congenital heart disease adding functional information undetectable with other imaging modalities. (C) 2013 Elsevier Inc. All rights reserved.