The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium.
The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium.
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DOI：
10.3390/ijms19102885
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发表时间：
2018-09-22
影响因子：
5.6
通讯作者：
Raggi C
中科院分区：
文献类型：
--
作者：
Gentilini A;Pastore M;Marra F;Raggi C
胆管癌（CCA）是一种严重的和大多数难治性胆管上皮细胞腺癌。CCA的一个典型特征是其高度促结缔组织增生的微环境，含有纤维化结缔组织和大量浸润肿瘤上皮的免疫细胞（T淋巴细胞、自然杀伤（NK）细胞和巨噬细胞）。这种强烈的结缔组织增生是由各种可溶性因子和信号协调的，这表明在形成肿瘤生长许可微环境中起着关键作用，该微环境是CCA不良临床结果的原因。事实上，间质不仅提供了丰富的促进CCA启动、生长和进展的因子，而且对治疗结果产生不利影响。本文综述了微环境中肿瘤-间质信号传导对CCA发展和进展的重要调控作用。通过成纤维细胞组分和免疫细胞亚群鉴定CCA分泌因子可能为这种类型的癌症的药理学靶向提供充足的机会。
Cholangiocarcinoma (CCA) is a severe and mostly intractable adenocarcinoma of biliary epithelial cells. A typical feature of CCA is its highly desmoplastic microenvironment containing fibrogenic connective tissue and an abundance of immune cells (T lymphocytes, Natural Killer (NK) cells, and macrophages) infiltrating tumor epithelium. This strong desmoplasia is orchestrated by various soluble factors and signals, suggesting a critical role in shaping a tumor growth-permissive microenvironment that is responsible for CCA poor clinical outcome. Indeed stroma not only provides an abundance of factors that facilitate CCA initiation, growth and progression, but also a prejudicial impact on therapeutic outcome. This review will give an overview of tumor-stroma signaling in a microenvironment critically regulating CCA development and progression. Identification of CCA secreted factors by both the fibroblast component and immune cell subsets might provide ample opportunities for pharmacological targeting of this type of cancer.
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影响因子：
13.5
作者：
Fingas, Christian D.;Bronk, Steven F.;Werneburg, Nathan W.;Mott, Justin L.;Guicciardi, Maria E.;Cazanave, Sophie C.;Mertens, Joachim C.;Sirica, Alphonse E.;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
影响因子：
13.5
作者：
Claperon, Audrey;Mergey, Martine;Fouassier, Laura
通讯作者：
Fouassier, Laura
影响因子：
6.7
作者：
Fingas, Christian D.;Mertens, Joachim C.;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
影响因子：
5.6
作者：
Cadamuro M;Brivio S;Spirli C;Joplin RE;Strazzabosco M;Fabris L
通讯作者：
Fabris L
DOI：
10.3978/j.issn.2224-4778.2013.04.02
发表时间：
2013-07
期刊：
Translational gastrointestinal cancer
影响因子：
--
作者：
Cadamuro M;Morton SD;Strazzabosco M;Fabris L
通讯作者：
Fabris L