Interaction of excitable waves emitted from two defects by pulsed electric fields
Interaction of excitable waves emitted from two defects by pulsed electric fields
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DOI：
10.1016/j.cnsns.2017.05.034
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Sun, Wei-Gang
中科院分区：
文献类型：
--
作者：
Chen, Jiang-Xing;Zhang, Han;Sun, Wei-Gang
响应于脉冲电场，可激发介质中的空间分布的不均匀性可以作为用于产生壁内电波的成核位点，这种现象被称为“来自不均匀性的波发射”（WEH效应）。心脏组织中的异质性在WEH效应中强烈地相互影响。我们研究了具有两个缺陷的介质中的WEH效应。研究了脉冲直流电场（DEF）和旋转电场（REF）对两种缺陷的作用及其相互作用。所施加电场的方向不仅在产生波传播所需的最小电场中起主要作用，而且在附近缺陷的影响程度中起主要作用。两个缺陷之间的距离，即缺陷的密度，也在WEH效应中起重要作用。通常，当施加脉冲电场时，REF优于DEF。这些结果可能有助于改善WEH的应用，特别是在伴有纤维化和瘢痕形成的老年患者中，这些患者伴随着更高的电导率不连续发生率。(C)2017爱思唯尔B.V.保留所有权利。
In response to a pulsed electric field, spatial distributed heterogeneities in excitable media can serve as nucleation sites for the generation of intramural electrical waves, a phenomenon called as "wave emission from heterogeneities" (WEH effect). Heterogeneities in cardiac tissue strongly influence each other in the WEH effect. We study the WEH effect in a medium possessing two defects. The role of two defects and their interaction by pulsed DC electric fields (DEF) and rotating electric fields (REF) are investigated. The direction of the applied electric field plays a major role not only in the minimum electrical field necessary to originate wave propagation, but also in the degree of influences of nearby defects. The distance between two defects, i.e. the density of defects, also play an important role in the WEH effect. Generally, the REF is better than the DEF when pulsed electric fields are applied. These results may contribute to the improved application of WEH, especially in older patients with fibrosis and scarring, which are accompanied by a higher incidence of conductivity discontinuities. (C) 2017 Elsevier B.V. All rights reserved.