Adenosine(5')tetraphospho(5')adenosine-binding protein of calf thymus.
Adenosine(5')tetraphospho(5')adenosine-binding protein of calf thymus.
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小牛胸腺的腺苷(5)四磷酸(5)腺苷结合蛋白。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Feldman
中科院分区：
文献类型：
--
作者：
E. Rapaport;L. Feldman
An adenosine(5')tetraphospho(5')adenosine (Ap4A) binding protein has been purified from calf thymus. The protein is comprised of a single polypeptide of Mr 54000 and is capable of high-affinity (Kd = 13 microM) binding of Ap4A with great substrate specificity. The Ap4A binding protein has been isolated in two forms: a 'free', or non-polymerase-bound, form which predominates, and a similar form which copurifies with DNA polymerase alpha, but which can be resolved from it. The free form of Ap4A binding protein contains associated adenosine(5')tetraphospho(5')adenosine phosphohydrolase (Ap4Aase) activity, while the form resolved from DNA polymerase alpha contains no such activity. The Ap4Aase activity, which catalyzes the phosphohydrolysis of Ap4A to ATP and AMP, is strongly inhibited by low levels (50-100 microM) of Zn2+ without any effect on the Ap4A binding protein activity. This difference in associated Ap4Aase activity between free and polymerase-bound forms of the protein, plus the copurification mentioned above, indicate a specific association between Ap4A binding protein and DNA polymerase alpha.
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从 HeLa 细胞 DNA 聚合酶 α 的多蛋白形式中分离出二腺苷 5,5"-P1,P4-四磷酸结合亚基。
DOI：
10.1073/pnas.80.16.4931
发表时间：
1983
影响因子：
11.1
作者：
Baril,E;Bonin,P;Burstein,D;Mara,K;Zamecnik,P
通讯作者：
Zamecnik,P
二腺苷 5,5"-P1,P4-四磷酸结合蛋白与 HeLa 细胞 DNA 聚合酶 α 的关联。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Rapaport,E;Zamecnik,PC;Baril,EF
通讯作者：
Baril,EF
使用单链 DNA 模板实现 DNA 聚合酶 α 活性的辅助蛋白。
DOI：
10.1073/pnas.78.8.4723
发表时间：
1981
影响因子：
11.1
作者：
Lamothe,P;Baril,B;Chi,A;Lee,L;Baril,E
通讯作者：
Baril,E
P1,P4-Di(腺苷-5)四磷酸抑制劳斯肉瘤病毒 pp60src 对免疫球蛋白 G 的磷酸化。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Maness,PF;Perry,ME;Levy,BT
通讯作者：
Levy,BT