Extrinsic and intrinsic regulation of axon regeneration at a crossroads.
Extrinsic and intrinsic regulation of axon regeneration at a crossroads.
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DOI：
10.3389/fnmol.2015.00027
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发表时间：
2015
影响因子：
4.8
通讯作者：
Fournier AE
中科院分区：
文献类型：
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作者：
Kaplan A;Ong Tone S;Fournier AE
损伤脊髓的修复是医学上的一个重大挑战。由成年中枢神经系统（CNS）神经元引起的有限的内在再生反应进一步受到表征受损CNS的星形胶质细胞增生、髓鞘碎片和瘢痕组织的阻碍。改善轴突再生和恢复可以通过靶向外源性因子以及通过促进神经元内源性生长调节剂来引起。我们对再生的内在和外在调节因子的分子基础的了解迅速扩大，从而产生了有希望的新靶点来促进修复。有趣的是，某些神经元内源性生长调节剂正在成为既刺激生长又缓解再生的外源性抑制的有希望的靶点。脊髓损伤的内在和外在方面之间的这种交叉点是有效治疗这种未满足需求的有希望的目标。
Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosis, myelin debris and scar tissue that characterize the damaged CNS. Improved axon regeneration and recovery can be elicited by targeting extrinsic factors as well as by boosting neuron-intrinsic growth regulators. Our knowledge of the molecular basis of intrinsic and extrinsic regulators of regeneration has expanded rapidly, resulting in promising new targets to promote repair. Intriguingly certain neuron-intrinsic growth regulators are emerging as promising targets to both stimulate growth and relieve extrinsic inhibition of regeneration. This crossroads between the intrinsic and extrinsic aspects of spinal cord injury is a promising target for effective therapies for this unmet need.
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影响因子：
16.2
作者：
Kadoya, Ken;Tsukada, Shingo;Lu, Paul;Coppola, Giovanni;Geschwind, Dan;Filbin, Marie T.;Blesch, Armin;Tuszynski, Mark H.
通讯作者：
Tuszynski, Mark H.
影响因子：
5.3
作者：
Fournier, AE;Takizawa, BT;Strittmatter, SM
通讯作者：
Strittmatter, SM
影响因子：
5.3
作者：
Alabed, Yazan Z.;Pool, Madeline;Fournier, Alyson E.
通讯作者：
Fournier, Alyson E.
影响因子：
5.3
作者：
Auer M;Schweigreiter R;Hausott B;Thongrong S;Höltje M;Just I;Bandtlow C;Klimaschewski L
通讯作者：
Klimaschewski L
影响因子：
25
作者：
通讯作者：
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