Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5.
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溶血磷脂酰胆碱通过调节脂肪酸代谢酶长链酰基辅酶A合酶5抑制肺癌细胞增殖
DOI：
10.1002/ctm2.1180
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发表时间：
2023-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Lung cancer is a widespread malignancy with a high death rate and disorder of lipid metabolism. Lysophosphatidylcholine (lysoPC) has anti‐tumour effects, although the underlying mechanism is not entirely known. The purpose of this study aims at defining changes in lysoPC in lung cancer patients, the effects of lysoPC on lung cancer cells and molecular mechanisms. Lung cancer cell sensitivity to lysoPC was evaluated and decisive roles of long‐chain acyl‐coenzyme A synthase 5 (ACSL5) in lysoPC regulation were defined by comprehensively evaluating transcriptomic changes of ACSL5‐downregulated epithelia. ACSL5 over‐expressed in ciliated, club and Goblet cells in lung cancer patients, different from other lung diseases. LysoPC inhibited lung cancer cell proliferation, by inducing mitochondrial dysfunction, altering lipid metabolisms, increasing fatty acid oxidation and reprograming ACSL5/phosphoinositide 3‐kinase/extracellular signal‐regulated kinase‐regulated triacylglycerol‐lysoPC balance. Thus, this study provides a general new basis for the discovery of reprogramming metabolisms and metabolites as a new strategy of lung cancer precision medicine. LysoPC reprograms lipid metabolisms by increasing the accumulation of fatty acids and activating acyl‐CoA‐dominated metabolic mode under the control and regulation of ACSL5. LysoPC up‐regulates the expression of ACSL5 and activates the ACSL5‐oriented lipid metabolism by promoting the phosphorylation of PI3K/mTOR and Ras/ERK signal pathways. LysoPC inhibited lung cancer cell proliferation by promoting ACSL5, leading to the disorder of FA degradation.
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影响因子：
5.5
作者：
Buller, Carolyn L.;Loberg, Robert D.;Brosius, Frank C., III
通讯作者：
Brosius, Frank C., III
影响因子：
8.1
作者：
Bowman TA;O'Keeffe KR;D'Aquila T;Yan QW;Griffin JD;Killion EA;Salter DM;Mashek DG;Buhman KK;Greenberg AS
通讯作者：
Greenberg AS
影响因子：
7.7
作者：
Li LO;Grevengoed TJ;Paul DS;Ilkayeva O;Koves TR;Pascual F;Newgard CB;Muoio DM;Coleman RA
通讯作者：
Coleman RA
影响因子：
5.2
作者：
Kaemmerer E;Gassler N
通讯作者：
Gassler N
影响因子：
8.9
作者：
Grevengoed TJ;Klett EL;Coleman RA
通讯作者：
Coleman RA