Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
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DOI：
10.1016/j.neures.2008.12.004
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Kato, Tadafumi
中科院分区：
文献类型：
--
作者：
Washizuka, Shinsuke;Iwamoto, Kazuya;Kato, Tadafumi
一些研究表明双相情感障碍（BD）和精神分裂症（SZ）存在线粒体异常。我们之前报道了日本双相I型障碍（BDI）患者淋巴母细胞样细胞系（LCLs）中线粒体复合体I亚基基因NDUFV2在18p11的表达降低。最近有报道称，与对照组相比，白种人BDI患者lcl中NDUFV2 mRNA水平没有差异。在本研究中，我们检测了NDUFV2在扩展型日本lcl和不同种族lcl中的表达变化。与我们之前的研究相比，本研究发现了类似的趋势，因为在日本BDI患者的lcl中发现了NDUFV2的表达降低（p = 0.03）。我们还发现，与对照组相比，日本双相情感障碍患者的NDUFV2表达上调（p = 0.001），而高加索SZ患者的NDUFV2 mRNA水平下调（p = 0.000001）。此外，我们发现，与对照组相比，用丙戊酸盐（一种情绪稳定剂）培养的LCLs中NDUFV2的mRNA表达显著增加（p = 0.02）。我们的研究进一步证明了NDUFV2在BD和SZ中的生物学意义。(C) 2008爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
Several studies have suggested mitochondrial abnormality in bipolar disorder (BD) and schizophrenia (SZ). We have previously reported the decreased expression of mitochondrial complex I subunit gene, NDUFV2 at 18p11, in lymphoblastoid cell lines (LCLs) from Japanese patients with bipolar I disorder (BDI). Recently it was reported that no differences were found in NDUFV2 mRNA levels in LCLs of Caucasian BDI patients compared with controls. In this study, we tested the altered expression of NDUFV2 in extended Japanese LCLs and LCLs from different ethnic groups. Similar tendency was found in the current study compared with our previous study, since decreased expression of NDUFV2 in LCLs from Japanese patients with BDI was found (p = 0.03). We also found that the expressions of NDUFV2 were up-regulated in those from patients with Japanese bipolar 11 disorder (p = 0.001) and the mRNA levels of this gene were down-regulated in Caucasian SZ (p = 0.000001) compared with controls. Furthermore, we revealed that the mRNA expression of NDUFV2 in LCLs cultured with valproate, one of mood stabilizers, were significantly increased compared with controls (p = 0.02). Our study presented the further evidence of biological significance of NDUFV2 in BD and SZ. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.