T2* mapping of hip joint cartilage in various histological grades of degeneration
T2* mapping of hip joint cartilage in various histological grades of degeneration
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DOI：
10.1016/j.joca.2012.03.011
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发表时间：
2012-07-01
影响因子：
7
通讯作者：
Zilkens, C.
中科院分区：
文献类型：
--
作者：
Bittersohl, B.;Miese, F. R.;Zilkens, C.
目标：方法：对21例骨关节炎（OA）不同组织学严重程度的股骨头标本进行磁共振成像（MRI）和T2* 标测，包括用于软骨形态评估的三维（3D）双回波稳态（DESS）序列和用于T2* 标测的3D多回波数据图像组合（MEDIC）序列。随后，在所有标本中进行组织学评估，以将T2* 映射的观察结果与组织学分析相关联。根据Mankin评分，将组织学变化确定为4个等级：0级（Mankin评分0-4）、I级（评分5-8）、II级（评分9-10）和III级（评分11-14）。结果：T2* 值随软骨退变程度的增加而显著降低（总P值
Objective: To evaluate T2* values in various histological severities of osteoarthritis (OA).Method: Magnetic resonance imaging (MRI) and T2* mapping including a three-dimensional (3D) double-echo steady-state (DESS) sequence for morphological cartilage assessment and a 3D multiecho data image combination (MEDIC) sequence for T2* mapping were conducted in 21 human femoral head specimens with varying severities of OA. Subsequently, histological assessment was undertaken in all specimens to correlate the observations of T2* mapping with histological analyses. According to the Mankin score, four grades of histological changes were determined: grade 0 (Mankin scores of 0-4), grade I (scores of 5-8), grade II (scores of 9-10), and grade III (scores of 11-14). For reliability assessment, cartilage T2* measurements were repeated after 4 weeks in 10 randomly selected femoral head specimens.Results: T2* values decreased significantly with increasing cartilage degeneration (total P-values