SERUM IGG AND IGG SUBCLASS CONTENTS IN DIFFERENT GM PHENOTYPES
SERUM IGG AND IGG SUBCLASS CONTENTS IN DIFFERENT GM PHENOTYPES
复制标题
DOI：
10.1111/j.1365-3083.1993.tb01750.x
复制
发表时间：
1993-02-01
影响因子：
3.7
通讯作者：
OXELIUS, VA
中科院分区：
文献类型：
--
作者：
OXELIUS, VA
正常人群中存在不同的血清IgG和IgG亚类水平。对157名高加索献血者进行了IgG亚类位点上的互惠Gm等位型调查，即IgG1， G1m(f)和G1m(a)；对于IgG2， G2m(n), G2m（”）；对于IgG3， G3m(b)和G3m(g)，并在七种最常见的Gm表型中进行亚组。给出了转基因表型和单倍型的频率，包括以前鲜为人知的G2m（n，”）杂合个体的数量。给出了不同Gm表型的血清中IgG、IgG1、IgG2、IgG3和IgG4的平均+/- SD值和范围。与其他表型相比，Gm（f, ",b/f, ",b）表型的IgG含量显著降低，IgG2水平也显著降低。IgG3水平在Gm（a, ",g/a, ",g）表型中显著低于其他表型。这些数据暗示了Gm（f，“，b/f，”，b）和Gm（a，“，g/a，”，g）表型导致IgG抗体数量较低的重要性。在评估IgG亚类缺陷时，应考虑低反应Gm（f, ",b/f, ",b）和Gm（a, ",g/a, ",g）表型的范围。
Different serum IgG and IgG subclass levels were found among Gm phenotypes of a normal population. One hundred and fifty-seven Caucasian blood donors were investigated for the reciprocal Gm allotypes on IgG subclass loci namely: for IgG1, G1m(f) and G1m(a); for IgG2, G2m(n) and G2m(''); and for IgG3, G3m(b) and G3m(g), and subgrouped in the seven most common Gm phenotypes. The frequencies of Gm phenotypes and haplotypes were given, including numbers of the previously little known G2m(n,'') heterozygous individuals. Mean serum quantities +/- SD and range of IgG, IgG1, IgG2, IgG3 and IgG4 were given for different Gm phenotypes. The IgG content was significantly lower in the Gm(f,'',b/f,'',b) phenotype in which the IgG2 levels were also significantly lower, compared with values of the other phenotypes. IgG3 levels were significantly lower in the Gm(a,'',g/a,'',g) phenotype compared with other phenotypes. These data imply the importance of Gm(f,'',b/f,'',b) and Gm(a,'',g/a,'',g) phenotypes causing lower amounts of IgG antibodies. In evaluating IgG subclass deficiency, the range for the low responding Gm(f,'',b/f,'',b) and Gm(a,'',g/a,'',g) phenotypes should be considered.