Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients
Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients
复制标题
癌胚抗原正常表明胃癌患者可从围手术期化疗中获益
DOI：
10.3748/wjg.v18.i29.3910
复制
发表时间：
2012-08-07
影响因子：
4.3
通讯作者：
Qian, Chao-Nan
中科院分区：
文献类型：
--
作者：
Chen, Shi;Chen, Ying-Bo;Qian, Chao-Nan
目的：评估术前血清癌胚抗原（CEA）作为预测局部晚期胃癌患者围手术期化疗的生存率的指标。方法：我们回顾性研究了2005年1月至2009年12月在中山大学附属肿瘤医院接受D2胃切除术联合化疗的228例胃癌患者。其中，168例患者接受了6-12个周期的以奥沙利铂为基础的辅助（术后）化疗，60例患者接受了围手术期化疗（术前2个周期的FOLFOX 6或XALFOX，术后4-10个周期）。采用酶免疫法测定血清CEA。结果：血清CEA升高组中，围手术期化疗组与辅助化疗组的生存时间差异无统计学意义（P > 0. 05）。而CEA正常组围手术期化疗患者生存时间较长。多因素分析显示，T分期和淋巴结转移率是影响患者预后的独立因素。术前CEA水平正常的患者围手术期化疗可提高总生存率（P = 0.070）。结论：术前CEA水平正常是围手术期化疗患者生存的预测指标。(C)2012年百世登。All rights reserved.
AIM: To evaluate pretreatment serum carcinoembryonic antigen (CEA) as a predictor of survival for patients with locally advanced gastric cancer receiving perioperative chemotherapy.METHODS: We retrospectively studied a cohort of 228 gastric cancer patients who underwent D2 gastrectomy combined with chemotherapy at the Sun Yat-sen University Cancer Center between January 2005 and December 2009. Among them, 168 patients received 6-12 cycles of oxaliplatin-based adjuvant (post-operative) chemotherapy, while 60 received perioperative chemotherapy (2 cycles of FOLFOX6 or XELOX before surgery and 4-10 cycles after surgery). Serum CEA was measured using an enzyme immunoassay. The follow-up lasted until December 2010.RESULTS: In the group that had elevated serum CEA, the difference in survival time between patients receiving perioperative chemotherapy and those receiving adjuvant chemotherapy had no statistical significance (P > 0.05). However, in the group that had normal serum CEA, patients receiving perioperative chemotherapy had a longer survival time. In multivariate analysis, T staging and lymph node metastatic rate were independent prognostic factors for the patients. Perioperative chemotherapy improved the overall survival of patients who had a normal pretreatment CEA level (P = 0.070).CONCLUSION: Normal pretreatment serum CEA is a predictor of survival for patients receiving perioperative chemotherapy. (C) 2012 Baishideng. All rights reserved.