Regulation and Function of Versatile Aerobic and Anaerobic Respiratory Metabolism in Pseudomonas aeruginosa.
Regulation and Function of Versatile Aerobic and Anaerobic Respiratory Metabolism in Pseudomonas aeruginosa.
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DOI：
10.3389/fmicb.2011.00103
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发表时间：
2011
影响因子：
5.2
通讯作者：
Arai H
中科院分区：
文献类型：
--
作者：
Arai H
铜绿假单胞菌是一种广泛分布的机会致病菌，它栖息于土壤和水以及动物、人类和植物宿主相关的环境中。它的普遍性应归功于它非常灵活的能量代谢。铜绿假单胞菌具有高度分支的呼吸链，其末端由多个末端氧化酶和脱氮酶终止。在铜绿假单胞菌细胞中已经鉴定了五种用于有氧呼吸的末端氧化酶。其中cbb 3 -1氧化酶、cbb 3 -2氧化酶和aa 3氧化酶是细胞色素c氧化酶，另外两种是bo 3氧化酶和氰化物不敏感氧化酶是醌醇氧化酶。每种氧化酶都具有对氧的特异性亲和力、能量偶联效率以及对各种胁迫（如氰化物和活性氮物质）的耐受性。这些末端氧化酶根据环境条件的不同而不同地使用。铜绿假单胞菌还具有一套完整的反硝化酶，其通过亚硝酸盐、一氧化氮（NO）和一氧化二氮将硝酸盐还原为分子氮。这些氮氧化物作为替代电子受体，使铜绿假单胞菌在厌氧条件下生长。脱氮酶之一，NO还原酶，也被预期用于解毒由宿主免疫防御系统产生的NO。控制这些需氧和厌氧呼吸酶的表达将有助于铜绿假单胞菌适应广泛的环境条件，包括感染宿主。本文就铜绿假单胞菌呼吸酶的特性及呼吸酶基因表达的调控系统作一综述。
Pseudomonas aeruginosa is a ubiquitously distributed opportunistic pathogen that inhabits soil and water as well as animal-, human-, and plant-host-associated environments. The ubiquity would be attributed to its very versatile energy metabolism. P. aeruginosa has a highly branched respiratory chain terminated by multiple terminal oxidases and denitrification enzymes. Five terminal oxidases for aerobic respiration have been identified in the P. aeruginosa cells. Three of them, the cbb3-1 oxidase, the cbb3-2 oxidase, and the aa3 oxidase, are cytochrome c oxidases and the other two, the bo3 oxidase and the cyanide-insensitive oxidase, are quinol oxidases. Each oxidase has a specific affinity for oxygen, efficiency of energy coupling, and tolerance to various stresses such as cyanide and reactive nitrogen species. These terminal oxidases are used differentially according to the environmental conditions. P. aeruginosa also has a complete set of the denitrification enzymes that reduce nitrate to molecular nitrogen via nitrite, nitric oxide (NO), and nitrous oxide. These nitrogen oxides function as alternative electron acceptors and enable P. aeruginosa to grow under anaerobic conditions. One of the denitrification enzymes, NO reductase, is also expected to function for detoxification of NO produced by the host immune defense system. The control of the expression of these aerobic and anaerobic respiratory enzymes would contribute to the adaptation of P. aeruginosa to a wide range of environmental conditions including in the infected hosts. Characteristics of these respiratory enzymes and the regulatory system that controls the expression of the respiratory genes in the P. aeruginosa cells are overviewed in this article.
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影响因子：
5
作者：
Attila, Can;Ueda, Akihiro;Wood, Thomas K.
通讯作者：
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影响因子：
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影响因子：
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作者：
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