ALTERATION OF TUMOR-GROWTH BY ASPIRIN AND INDOMETHACIN - STUDIES WITH 2 TRANSPLANTABLE TUMORS IN MOUSE
ALTERATION OF TUMOR-GROWTH BY ASPIRIN AND INDOMETHACIN - STUDIES WITH 2 TRANSPLANTABLE TUMORS IN MOUSE
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DOI：
10.1016/0014-2999(76)90044-3
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发表时间：
1976-01-01
影响因子：
5
通讯作者：
BEAVEN, MA
中科院分区：
文献类型：
--
作者：
HIAL, V;HORAKOVA, Z;BEAVEN, MA
每日口服阿司匹林或吲哚美辛可延缓小鼠实验肿瘤的生长。阿司匹林150mg /kg，每日2次，对移植肥大细胞腹水瘤（P815）的生长抑制率为39 ~ 43% (P < 0.001)，对移植Lewis肺癌的生长抑制率为52% (P < 0.025)，但对机体生长无不良影响。腹水肿瘤的总血清素、组胺和组氨酸脱羧酶含量也降低，尿中胺的排泄量也降低。吲哚美辛3、5 mg/kg组小鼠腹水肿瘤生长分别减少40% （P < 0.01）和80% （P < 0.001）。随着吲哚美辛剂量的增加，一半接种了肿瘤的动物没有发现肿瘤，尽管在动物身上有明显的吲哚美辛毒性迹象（身体生长减慢，胃损伤）。
Oral daily administration of aspirin or indomethacin retarded growth of experimental tumors in mice. Aspirin treatment, 150 mg/kg twice daily, inhibited growth of a transplantable mast cell ascites tumor (P815) by 39-43% (P < 0.001) and a s.c. transplanted Lewis lung carcinoma by 52% (P < 0.025) without adversely affecting body growth. The total serotonin, histamine and histidine decarboxylase content of the ascites tumor was also reduced, as was urinary excretion of the amines. Treatment with 3 and 5 mg/kg indomethacin resulted in 40% (P < 0.01) and 80% (P < 0.001) reduction, respectively, in ascites tumor growth. With the higher dose of indomethacin, no tumor was observed in half of the animals inoculated with tumor, although signs of indomethacin toxicity (reduced body growth, gastric lesion) were evident in the animals.