Age-Specific Risk of Incident Prostate Cancer and Risk of Death from Prostate Cancer Defined by the Number of Affected Family Members
Age-Specific Risk of Incident Prostate Cancer and Risk of Death from Prostate Cancer Defined by the Number of Affected Family Members
复制标题
DOI：
10.1016/j.eururo.2010.02.002
复制
发表时间：
2010-08-01
期刊：
影响因子：
23.4
通讯作者：
Hemminki, Kari
中科院分区：
文献类型：
--
作者：
Brandt, Andreas;Bermejo, Justo Lorenzo;Hemminki, Kari
背景：家族性前列腺癌（PCa）风险的全面评估与以往一样重要，为临床咨询和筛查建议提供基础。目的：我们的目的是根据患前列腺癌的一级亲属的数量和年龄确定前列腺癌的年龄特异性风险和死亡风险。设计、设置和参与者：瑞典全国家庭癌症数据库包括1958年至2006年间1,180万人及其癌症的记录。1961年至2006年期间，研究人员对数据库中所有有明确父母的男性（约390万人）进行了跟踪调查。该研究包括26651例PCa患者，其中5623例为家族性。测量方法：根据患病父亲和兄弟的数量和年龄，计算前列腺癌的年龄特异性风险比（HRs）和前列腺癌死亡风险比（HRs）。结果与局限性：前列腺癌诊断的hr随患病亲属数量的增加而增加，随年龄的增加而降低。男性的hr最高
Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations.Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives.Design, setting, and participants: The nationwide Swedish Family-Cancer Database includes a record of >11.8 million individuals and their cancers from 1958 to 2006. All men from the database with identified parents (>3.9 million individuals) were followed between 1961 and 2006. The study included 26 651 PCa patients, of whom 5623 were familial.Measurements: The age-specific hazard ratios (HRs) of PCa and the HRs of death from PCa were calculated according to the number and age of affected fathers and brothers.Results and limitations: The HRs of PCa diagnosis increased with the number of affected relatives and decreased with increasing age. The highest HRs were observed for men