INTERACTIONS BETWEEN ALCOHOL AND BETA-CAROTENE IN PATIENTS WITH ALCOHOLIC LIVER-DISEASE
INTERACTIONS BETWEEN ALCOHOL AND BETA-CAROTENE IN PATIENTS WITH ALCOHOLIC LIVER-DISEASE
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DOI：
10.1093/ajcn/60.3.430
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发表时间：
1994-09-01
影响因子：
7.1
通讯作者：
LIEBER, CS
中科院分区：
文献类型：
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作者：
AHMED, S;LEE, MA;LIEBER, CS
我们发现，酗酒者的血浆β -胡萝卜素浓度低于对照组，但重度饮酒者（大于或等于200 g/d）的β -胡萝卜素含量约为饮酒者的两倍（P < 0.01），血浆β -胡萝卜素与酒精摄入量之间存在显著相关性（r = 0.6, P < 0.001）。当在控制饮食的情况下给住院的酗酒者服用β -胡萝卜素头套（30-60毫克/天）时，肝硬化患者的血浆β -胡萝卜素反应远低于没有服用的患者；而后者的β -胡萝卜素浓度则低于对照组。血浆视黄醇、α -生育酚和其他类胡萝卜素，如番茄红素，没有显著差异。我们的结论是，大量饮酒会使血浆β -胡萝卜素相对增加，而在肝损伤，特别是肝硬化患者中，血浆β -胡萝卜素会降低。在这些患者中，补充β -胡萝卜素可能是合理的，但这应该与控制饮酒相结合，因为可能的肝毒性酒精- β -胡萝卜素相互作用。
We found lower plasma beta-carotene concentrations in alcoholics than in control subjects, but heavy drinkers (greater than or equal to 200 g/d) had about twice the beta-carotene of those drinking less (P < 0.01), with a significant correlation between plasma beta-carotene and alcohol intake (r = 0.6, P < 0.001). When beta-carotene beadlets (30-60 mg/d) were administered to hospitalized alcoholics given controlled diets, those with cirrhosis had a much lower plasma beta-carotene response than those without; the latter in turn responded with lower beta-carotene concentrations than did control subjects. Plasma retinol, alpha-tocopherol, and other carotenoids, such as lycopene, did not differ significantly. We concluded that plasma beta-carorene is relatively increased by heavy alcohol consumption, whereas in patients with liver damage, especially cirrhosis, it is lowered. In these patients, beta-carotene supplementation may be justified, but this should be coupled with control of drinking because of possible hepatotoxic alcohol-beta-carotene interactions.