Kallikreins as biomarkers for prostate cancer.
Kallikreins as biomarkers for prostate cancer.
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DOI：
10.1155/2014/526341
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发表时间：
2014
影响因子：
--
通讯作者：
Hong SK
中科院分区：
文献类型：
--
作者：
Hong SK
前列腺特异性抗原 (PSA) 是激肽释放酶相关肽酶 15 个基因家族的成员，也称为激肽释放酶相关肽酶 3 (KLK3)，引入血液检测彻底改变了前列腺癌的检测和治疗。鉴于 PSA 与其他 KLK 基因家族成员之间的相似性以及 PSA 作为前列腺癌生物标志物的局限性（主要涉及诊断特异性），该基因家族其他成员以及 PSA 衍生物和亚型在前列腺癌治疗中的潜在作用已得到广泛研究。其中，测量不同分子形式的 PSA（游离、完整、复合 PSA 和 pro-PSA）与激肽释放酶相关肽酶 2 (KLK2)（也称为 hK2）相结合的方法被认为在增强前列腺癌的诊断方面具有特殊的前景。最近，应用一组四种激肽释放酶标记物的综合方法已被证明可以提高活检时预测前列腺癌风险的准确性。本综述概述了激肽释放酶，从 PSA 的过去和当前状况开始，总结了各种 KLK 作为前列腺癌诊断、预后和监测生物标志物的评估数据。
The introduction of testing for prostate-specific antigen (PSA), a member of the fifteen-gene family of kallikrein-related peptidases and also known as kallikrein-related peptidase 3 (KLK3), in blood has revolutionized both the detection and management of prostate cancer. Given the similarities between PSA and other KLK gene family members along with limitations of PSA as a biomarker for prostate cancer mainly in reference to diagnostic specificity, the potential roles of other members of this gene family as well as PSA derivatives and isoforms in the management of prostate cancer have been studied extensively. Of these, approaches to measure distinct molecular forms of PSA (free, intact, complexed PSA, and pro-PSA) combined with kallikrein-related peptidase 2 (KLK2), also known as hK2, have been considered holding particular promise in enhancing the diagnosis of prostate cancer. Recently, an integrated approach of applying a panel of four kallikrein markers has been demonstrated to enhance accuracy in predicting the risk of prostate cancer at biopsy. This review presents an overview of kallikreins, starting with the past and current status of PSA, summarizing published data on the evaluations of various KLKs as biomarkers in the diagnosis, prognostication, and monitoring of prostate cancer.
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影响因子：
6.6
作者：
BENSON, MC;WHANG, IS;COONER, WH
通讯作者：
COONER, WH
影响因子：
2.1
作者：
Darson, MF;Pacelli, A;Bostwick, DG
通讯作者：
Bostwick, DG
影响因子：
158.5
作者：
Barry, MJ
通讯作者：
Barry, MJ
DOI：
10.1093/jnci/95.12.868
发表时间：
2003-06-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Draisma, G;Boer, R;de Koning, HJ
通讯作者：
de Koning, HJ
影响因子：
6.6
作者：
D'Amico, AV;Cote, K;Schultz, D
通讯作者：
Schultz, D