Associations of pubertal stage and body mass index with cardiometabolic risk in Hong Kong Chinese children: A cross-sectional study.
Associations of pubertal stage and body mass index with cardiometabolic risk in Hong Kong Chinese children: A cross-sectional study.
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DOI：
10.1186/s12887-015-0446-0
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发表时间：
2015-09-24
期刊：
影响因子：
2.4
通讯作者：
Kong AP
中科院分区：
文献类型：
--
作者：
Chan NP;Choi KC;Nelson EA;Chan JC;Kong AP
青春期与青春期的心脏代谢危险因素（CMRF）聚集有关，这些因素在以后的生活中表现出来。虽然人体测量变量，如体重指数（BMI）可以预测儿童和青少年的心脏代谢风险，但尚不清楚青春期阶段和BMI之间是否存在与该年龄组心脏代谢风险相关的相互作用。本文探讨了香港中国儿童的青春期阶段和BMI与CMRF的关系。在1985名（95.1%）6至18岁的学生中进行了一项横断面校本研究。测量空腹血脂、血糖、血压、体重、身高和腰围。自我报告的青春期阶段问卷被用来评估参与者的青春期阶段。构建了两个心脏代谢风险评分α和β，以量化心脏代谢风险。心脏代谢风险评分α是指性别特异性、年龄校正腰围、身高校正收缩压和舒张压、空腹血糖、甘油三酯和低密度脂蛋白胆固醇的z评分之和，以及性别特异性、年龄校正高密度脂蛋白胆固醇的负z评分。心脏代谢风险评分β包括风险评分α的所有组成部分，腰围除外。BMI z评分（ZBMI）和青春期阶段的相互作用表明，男孩和女孩的心脏代谢风险评分α和β（分别为0.5%和0.8%）和（分别为0.7%和0.5%）的方差进一步增加。青春期阶段在男孩中对BMI与心脏代谢风险的关联具有交互作用，在女孩中可能具有类似但较小的影响。
Puberty is associated with a clustering of cardiometabolic risk factors (CMRFs) during adolescence that are manifested in later life. Although anthropometric variables such as body mass index (BMI) can predict cardiometabolic risk in children and adolescents, it is not clear whether there is an interaction between pubertal stage and BMI associated with cardiometabolic risk in this age group. This paper examines the association of pubertal stage and BMI with CMRFs in Hong Kong Chinese children. A cross-sectional school-based study was conducted among 1985 (95.1 %) students aged 6 to 18 years. Fasting lipid profile and plasma glucose, blood pressure, body weight, body height and waist circumference were measured. A self-reported pubertal stage questionnaire was used to assess pubertal stage of participants. Two cardiometabolic risk scores, alpha and beta, were constructed to quantify cardiometabolic risk. Cardiometabolic risk score alpha refers to the sum of z-scores of sex-specific, age-adjusted waist circumference, height-adjusted systolic and diastolic blood pressure, fasting plasma glucose, triglyceride and low-density lipoprotein cholesterol, and minus z-score of sex-specific age-adjusted high-density lipoprotein cholesterol. Cardiometabolic risk score beta includes all components of risk score alpha except waist circumference. The interaction of BMI z-score (ZBMI) and pubertal stage demonstrated a further increase in variance explained in both the cardiometabolic risk scores alpha and beta (0.5 % and 0.8 % respectively) in boys and (0.7 % and 0.5 % respectively) in girls. Pubertal stage has an interaction effect on the association of cardiometabolic risk by BMI in boys and may have a similar but lesser effect in girls.