Serum zinc levels in patients with iron deficiency anemia and its association with symptoms of iron deficiency anemia
Serum zinc levels in patients with iron deficiency anemia and its association with symptoms of iron deficiency anemia
复制标题
DOI：
10.1007/s00277-016-2628-8
复制
发表时间：
2016-04-01
影响因子：
3.5
通讯作者：
Bakan, Ebubekir
中科院分区：
文献类型：
--
作者：
Kelkitli, Engin;Ozturk, Nurinnisa;Bakan, Ebubekir
缺铁性贫血是一个重大的公共卫生问题，特别是在不发达国家和发展中国家。锌是多种酶的辅因子，在铁代谢中起着重要作用，因此缺锌与缺铁性贫血有关。本研究旨在探讨成人缺锌患者缺锌与缺锌症状的关系。这项研究包括43名IDA患者和43名健康对照组。所有患者都被要求提供详细的病史，并接受体检。血液学指标包括血红蛋白(Hb)、红细胞压积(Ht)、红细胞计数(RBC)、红细胞指数平均红细胞体积(MCV)、平均红细胞血红蛋白(DeDDe)、平均红细胞血红蛋白浓度(DeDDeD)和红细胞分布宽度(RDW)。根据世界卫生组织(WHO)定义的标准对贫血进行定义。在原子吸收光谱仪的火焰单元中测定血清锌水平。归因于铁缺乏或耗竭的症状，定义为疲劳、心肺症状、精神表现、上皮表现和神经肌肉症状，也被记录和分类。贫血组血清锌水平(103.51±34.64mU/dL)低于对照组(256.92±88.54mU/dL；<；0.001)。锌水平为99mU/dL的患者的精神症状(p<；0.001)、心肺症状(p=0.004)、不宁腿综合征(p=0.016)和上皮表现(p<；0.001)的发生率显著高于锌水平为100mU/dL的患者。当血清锌水平与PICA比较时，没有发现统计学上的显著相关性(p=0.742)。锌是一种微量元素，在体内的几个过程中发挥作用，缺锌会加剧IDA症状。对于缺铁性贫血患者，应该考虑锌水平的测量和必要时的补充。
Iron deficiency anemia (IDA) is a major public health problem especially in underdeveloped and developing countries. Zinc is the co-factor of several enzymes and plays a role in iron metabolism, so zinc deficiency is associated with IDA. In this study, it was aimed to investigate the relationship of symptoms of IDA and zinc deficiency in adult IDA patients. The study included 43 IDA patients and 43 healthy control subjects. All patients were asked to provide a detailed history and were subjected to a physical examination. The hematological parameters evaluated included hemoglobin (Hb); hematocrit (Ht); red blood cell (erythrocyte) count (RBC); and red cell indices mean corpuscular volume (MCV), mean corpuscular hemoglobin (DeDDe), mean corpuscular hemoglobin concentration (DeDDeD), and red cell distribution width (RDW). Anemia was defined according to the criteria defined by the World Health Organization (WHO). Serum zinc levels were measured in the flame unit of atomic absorption spectrophotometer. Symptoms attributed to iron deficiency or depletion, defined as fatigue, cardiopulmonary symptoms, mental manifestations, epithelial manifestations, and neuromuscular symptoms, were also recorded and categorized. Serum zinc levels were lower in anemic patients (103.51 +/- 34.64 mu/dL) than in the control subjects (256.92 +/- 88.54 mu/dL; < 0.001). Patients with zinc level < 99 mu/dL had significantly more frequent mental manifestations (p < 0.001), cardiopulmonary symptoms (p = 0.004), restless leg syndrome (p = 0.016), and epithelial manifestations (p < 0.001) than patients with zinc level > 100 mu/dL. When the serum zinc level was compared with pica, no statistically significant correlation was found (p = 0.742). Zinc is a trace element that functions in several processes in the body, and zinc deficiency aggravates IDA symptoms. Measurement of zinc levels and supplementation if necessary should be considered for IDA patients.