The role of palliative radiation therapy in symptomatic locally advanced gastric cancer
The role of palliative radiation therapy in symptomatic locally advanced gastric cancer
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DOI：
10.1016/j.ijrobp.2006.08.070
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发表时间：
2007-02-01
影响因子：
7
通讯作者：
Zhu, Ming
中科院分区：
文献类型：
--
作者：
Tey, Jeremy;Back, Michael F.;Zhu, Ming
目的：评价单纯姑息性放射治疗(RT)治疗有症状局部进展期或复发性胃癌患者的疗效。方法与材料：对新加坡癌症研究所姑息治疗的有症状局部进展期或复发性胃癌患者进行回顾性分析。研究终点包括症状反应、中位生存期和治疗毒性(使用通用毒性标准v3.0[CTC]进行回顾性评分)。结果：1999年11月至2004年12月，33例局部进展期或复发胃癌患者仅采用RT进行姑息性治疗。中位年龄为76岁(38-90岁)。21例(%)患者在治疗时已知远处转移疾病。主要症状为出血(24例)、梗阻(8例)和疼痛(8例)。大多数患者接受30Gy10次照射(17例)。剂量分割方案从8Gy单次至40Gy16次不等。中位生存期为145天，精算12个月生存率为8%。出血患者中有54.3%(13/24)有反应(中位起效时间为140天)，梗阻患者中有25%(2/8)有反应(中位起效时间102天)，疼痛患者中有25%(2/8)有反应(中位起效时间105天)。未见明显的剂量反应。结论：单纯外照射放疗是一种有效且耐受性良好的胃癌局部姑息治疗方法，姑息治疗可延长大部分患者的生命。(C)2007年爱思唯尔公司。
Purpose: To review the outcome of palliative radiotherapy (RT) alone in patients with symptomatic locally advanced or recurrent gastric cancer.Methods and Materials: Patients with symptomatic locally advanced or recurrent gastric cancer who were managed palliatively with RT at The Cancer Institute, Singapore were retrospectively reviewed. Study end points included symptom response, median survival, and treatment toxicity (retrospectively scored using the Common Toxicity Criteria v3.0 [CTC]).Results: Between November 1999 and December 2004, 33 patients with locally advanced or recurrent gastric cancer were managed with palliative intent using RT alone. Median age was 76 years (range, 38-90 years). Twenty-one (64%) patients had known distant metastatic disease at time of treatment. Key index symptoms were bleeding (24 patients), obstruction (8 patients), and pain (8 patients). The majority of patients received 30 Gy/10 fractions (17 patients). Dose fractionation regimen ranged from an 8-Gy single fraction to 40 Gy in 16 fractions. Median survival was 145 days, actuarial 12-month survival 8%. A total of 54.3% of patients (13/24) with bleeding responded (median duration of response of 140 days), 25% of patients (2/8) with obstruction responded (median duration of response of 102 days), and 25% of patients (2/8) with pain responded (median duration of response of 105 days). No obvious dose-response was evident. One Grade 3 CTC equivalent toxicity was recorded.Conclusion: External beam RT alone is an effective and well tolerated modality in the local palliation of gastric cancer, with palliation lasting the majority of patients' lives. (c) 2007 Elsevier Inc.