Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis.
Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis.
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发表时间：
2010-04
影响因子：
5.5
通讯作者：
Y. Inagaki;Wei Tang;Li Zhang;Guanhua Du;Wenfang Xu;N. Kokudo
中科院分区：
文献类型：
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作者：
Y. Inagaki;Wei Tang;Li Zhang;Guanhua Du;Wenfang Xu;N. Kokudo
氨肽酶N (APN)/CD13是一种广泛表达的跨膜蛋白，在多种肿瘤细胞中检测到其表达改变。几种APN抑制剂已被开发出来，其中一些已被发现具有有效的抗癌作用。本文报道了新合成的羟肟酸衍生物24F作为APN抑制剂的抗癌作用。24F对肝细胞癌（HCC）细胞株HuH-7的侵袭有抑制作用，但在24F的分析浓度和孵育时间下，HuH-7的生长没有明显抑制。此外，血管内皮细胞与24F孵育被发现是有效的抑制血管生成现象。这些结果表明，新型APN抑制剂24F可能通过抑制肝癌细胞侵袭和血管生成来作为肝癌的抗癌药物。
Aminopeptidase N (APN)/CD13 is a widely expressed transmembrane protein and its altered expression has been detected in various cancer cells. Several APN inhibitors have been developed and some of them have been found to have effectiveness as anti-cancer agents. This article reports anti-cancer effects of a hydroxamic acid derivative 24F that was newly-synthesized as an APN inhibitor. 24F had the ability to inhibit the invasion of hepatocellular carcinoma (HCC) cell line HuH-7, although the growth of HuH-7 was not significantly inhibited at the analyzed concentrations of 24F and incubation times used. Furthermore, incubation of vascular endothelial cells with 24F was found to be effective for the suppression of the angiogenic phenomenon. These results suggest that the novel APN inhibitor 24F may work as an anti-cancer agent for HCC via inhibition of HCC cell invasion and angiogenesis.