Role of VEGF gene variability in longevity: A lesson from the Italian population
Role of VEGF gene variability in longevity: A lesson from the Italian population
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DOI：
10.1016/j.neurobiolaging.2007.05.003
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发表时间：
2008-12-01
影响因子：
4.2
通讯作者：
Comi, Giacomo Pietro
中科院分区：
文献类型：
--
作者：
Del Bo, Roberto;Ghezzi, Serena;Comi, Giacomo Pietro
血管内皮生长因子（VEGF）基因多态性与糖尿病、神经退行性疾病等多种疾病的发病风险增加有关，表明其功能并不局限于最初描述的血管作用。基于病理条件下未披露的VEGF保护作用，我们评估了VEGF变异性是否也可能是长寿的决定因素。在490名无血缘关系的意大利健康受试者中分析了VEGF基因启动子区域内的四种多态性（-2578C/A、-1190G/A、-1154G/A和-634G/C）。等位基因、基因型（-2578/AA vs -2578/CC: OR=2.08, p = 0.007; -1190/AA vs -1190/GG: OR= 2.01, p = 0.011）和单倍型（AAGG: 10.4% vs 14.9%, p = 0.03）频率分布在年轻/老年（25-84岁）和长寿（85-99岁）受试者之间发生显著变化。这些结果表明，VEGF基因变异可能是影响寿命的遗传因素之一。(c) 2007爱思唯尔公司版权所有。
Vascular endothelial growth factor (VEGF) gene polymorphisms have been associated with an increased risk of developing a wide variety of disorders from diabetes to neurodegenerative diseases suggesting functions not confined to its vascular effects originally described. Based on the VEGF protective roles undisclosed in pathological conditions', we evaluate whether VEGF variability might be a determinant also for longevity. Four polymorphisms (-2578C/A, -1190G/A, -1154G/A and -634G/C) within the VEGF gene promoter region it] 490 unrelated Italian healthy subjects have been analysed. Significant changes of allele, genotype (-2578/AA versus -2578/CC: OR=2.08, p = 0.007; -1190/AA versus -1190/GG: OR = 2.01, p = 0.011) and haplotype (AAGG: 10.4% versus 14.9%, p = 0.03) frequency distributions were observed between young/elderly (25-84 years old) and long-lived (85-99 years old) subjects. These results suggest that VEGF gene variability can be inserted among the genetic factors influencing the lifespan. (c) 2007 Elsevier Inc. All rights reserved.