Synthesis and rheological properties of polylactide/poly(ethylene glycol) multiblock copolymers
Synthesis and rheological properties of polylactide/poly(ethylene glycol) multiblock copolymers
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DOI：
10.1002/mabi.200500143
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发表时间：
2005-11-04
影响因子：
4.6
通讯作者：
Vert, M
中科院分区：
文献类型：
--
作者：
Li, F;Li, SM;Vert, M
以Zn粉为催化剂，在聚乙二醇存在下进行了丙交酯的开环聚合。羟基封端的PLA-PEG-PLA三嵌段共聚物与己二酰氯在温和条件下以不同的摩尔比偶联。以N-二甲氨基吡啶（DMAP）为催化剂进行偶联反应。采用IR、H-1 NMR、SEC和DSC等分析手段对PLA/PEG多嵌段共聚物进行了表征。用机械流变学方法研究了多嵌段共聚物的溶胶-凝胶转变特性。结果表明，随着共聚物分子量和溶液浓度的增加，共聚物的溶胶-凝胶转变温度和转变模量增加。
Ring-opening polymerization of D,L-lactide was carried out in the presence of poly(ethylene glycol), using Zn powder as catalyst. The hydroxyl-capped PLA-PEG-PLA triblock copolymers were coupled with adipoyl chloride at different molar ratios under mild conditions. N-Dimethylaminopyridine (DMAP) was used as catalyst of the coupling reaction. The resulting PLA/PEG multi-block copolymers were characterized by various analytical techniques such as IR, H-1 NMR, SEC, and DSC. Sol-gel transition properties of the multiblock copolymers were investigated by mechanical rheology. The data showed that the sol-gel transition temperature and the transition modulus increased with increasing molecular weight and the solution concentration of the multiblock copolymers.