Implementation and applications of dual-modality imaging
Implementation and applications of dual-modality imaging
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DOI：
10.1016/j.nima.2004.03.065
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发表时间：
2004-06-01
影响因子：
1.4
通讯作者：
Seo, Y
中科院分区：
文献类型：
--
作者：
Hasegawa, BH;Barber, WC;Seo, Y
在医学诊断中，可以使用具有正电子发射断层扫描或具有单光子发射计算机断层扫描的放射性核素成像来获取功能或生理数据。然而，可以使用X射线计算机断层摄影来采集解剖或结构数据。在双模态成像中，放射性核素和X射线检测器都被并入成像系统中，以允许在单个过程中采集功能和结构数据，而无需将患者从成像系统中移除。在临床环境中，双模态成像系统通常用于相对于患者的解剖结构定位放射性药物摄取。这有助于临床医生区分疾病与正常放射性药物积聚的区域，以改善诊断或癌症分期，或促进放射治疗或手术的计划。虽然双模态成像的最初应用是为人类的临床成像而开发的，但现在认识到这些系统对实验研究中涉及的小动物成像具有潜在的重要应用，包括哺乳动物生物学的基础研究和用于诊断或治疗疾病的新药的开发。(C)2004 Elsevier B.V.保留所有权利。
In medical diagnosis, functional or physiological data can be acquired using radionuclide imaging with positron emission tomography or with single-photon emission computed tomography. However, anatomical or structural data can be acquired using X-ray computed tomography. In dual-modality imaging, both radionuclide and X-ray detectors are incorporated in an imaging system to allow both functional and structural data to be acquired in a single procedure without removing the patient from the imaging system. In a clinical setting, dual-modality imaging systems commonly are used to localize radiopharmaceutical uptake with respect to the patient's anatomy. This helps the clinician to differentiate disease from regions of normal radiopharmaceutical accumulation, to improve diagnosis or cancer staging, or to facilitate planning for radiation therapy or surgery. While initial applications of dual-modality imaging were developed for clinical imaging on humans, it now is recognized that these systems have potentially important applications for imaging small animals involved in experimental studies including basic investigations of mammalian biology and development of new pharmaceuticals for diagnosis or treatment of disease. (C) 2004 Elsevier B.V. All rights reserved.