Effects of H1‐antagonists on discriminative stimulus effects of cocaine and methamphetamine in rats
Effects of H1‐antagonists on discriminative stimulus effects of cocaine and methamphetamine in rats
复制标题
H1拮抗剂对可卡因和甲基苯丙胺对大鼠辨别刺激作用的影响
DOI：
10.1097/00008877-199603000-00001
复制
发表时间：
1996
影响因子：
1.6
通讯作者：
M. Misawa
中科院分区：
文献类型：
--
作者：
T. Suzuki;T. Mori;K. Takamori;K. Onodera;M. Misawa
本文研究了H_1受体拮抗剂tripelennamine、chlorpheniramine和pyrilamine对可卡因和甲基苯丙胺辨别刺激效应的影响。训练大鼠区分可卡因（10 mg/kg，Lp.）或甲基苯丙胺（1.0 mg/kg，Lp.）和生理盐水，反应保持在固定比率10（FR 10）的食物递送时间表下。在泛化测试中，曲哌那明泛化到可卡因和甲基苯丙胺的辨别刺激效应，而扑尔敏仅泛化到可卡因。多巴胺受体拮抗剂氟哌啶醇减弱了曲吡胺和扑尔敏的这些概括作用。此外，tripelennamine和扑尔敏，但不是pyrilamine，加强了可卡因和甲基苯丙胺的歧视性刺激作用。这些结果表明，某些H1受体拮抗剂具有可卡因和/或甲基苯丙胺样的辨别刺激效应，这种效应可能是由多巴胺能系统介导的，因此，这些H1受体拮抗剂增强了可卡因和甲基苯丙胺的辨别刺激效应。
The effects of H1-antagonists, such as tripelennamine, chlorpheniramine and pyrilamine, on the discriminative stimulus effects of cocaine and methamphetamine in rats were examined. Rats were trained to discriminate between cocaine (10 mg/kg, Lp.) or methamphetamine (1.0 mg/kg, Lp.) and saline, with responses maintained under a fixed-ratio 10 (FR10) schedule of food delivery. In generalization tests, tripelennamine generalized to the discriminative stimulus effects of cocaine and methamphetamine, while chlorpheniramine only generalized to cocaine. These generalizations of tripelennamine and chlorpheniramine were attenuated by the dopamine receptor antagonist haloperidol. Furthermore, tripelennamine and chlorpheniramine, but not pyrilamine, potentiated the discriminative stimulus effects of cocaine and methamphetamine. These results suggest that some H1-antagonists possess cocaine- and/or methamphetamine-like discrminative stimulus effects which may be mediated by the dopaminergic system, and as a result the discriminative stimulus effects of cocaine and methamphetamine were potentiated by these H1-antagonists.