Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City
Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City
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DOI：
10.1002/oby.22923
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发表时间：
2020-09-01
期刊：
影响因子：
6.9
通讯作者：
Sharaiha, Reem Z.
中科院分区：
文献类型：
--
作者：
Hajifathalian, Kaveh;Kumar, Sonal;Sharaiha, Reem Z.
目的2019年新型冠状病毒病(新冠肺炎)引发了一场迅速扩大的全球大流行，患者表现出不同的疾病严重程度。鉴于肥胖在美国的高流行率，我们假设肥胖的存在可能在新冠肺炎患者的临床病程中发挥作用。方法对确诊为SARS冠状病毒2型的成人患者进行回顾性分析，总结其人口学特征、临床特征、实验室资料及临床转归。根据重症监护病房(ICU)入院或死亡和插管率的综合结果分析BMI(每平方米公斤数)。结果纳入患者约770例(男性占61%，平均年龄63.5岁)。肥胖患者更有可能出现发烧、咳嗽和呼吸急促。即使在调整了年龄、种族和肌钙蛋白水平后，肥胖也与ICU入院率或死亡率显著相关(RR=1.58，P=0.002)。结论与正常体重者相比，肥胖者罹患危重疾病导致ICU入院或死亡的风险增加。这项研究证实，肥胖是新冠肺炎疾病严重程度的主要风险因素，显著影响疾病表现和危重护理要求。
Objective The 2019 novel coronavirus disease (COVID-19) has triggered a rapidly expanding global pandemic in which patients exhibit a wide spectrum of disease severity. Given the high prevalence of obesity in the United States, we hypothesized that the presence of obesity may play a role in the clinical course of patients with COVID-19. Methods This is a retrospective review of adult patients admitted with confirmed severe acute respiratory syndrome coronavirus 2. Demographics, clinical characteristics, laboratory data, and clinical outcomes were abstracted. BMI (kilograms per meter squared) was analyzed with regard to a composite outcome of intensive care unit (ICU) admission or death and intubation rate. Results About 770 patients were included (61% male, mean age 63.5 years). Patients with obesity were more likely to present with fever, cough, and shortness of breath. Obesity was also associated with a significantly higher rate of ICU admission or death (RR = 1.58,P = 0.002) even after adjusting for age, race, and troponin level. Conclusions Patients with obesity had an increased risk for critical illness leading to ICU admission or death compared with normal weight individuals. This study confirms that obesity is a major risk factor for COVID-19 disease severity, significantly impacting disease presentation and critical care requirements.