The hypocalcemic effect of ethyl alcohol in rats and dogs.
The hypocalcemic effect of ethyl alcohol in rats and dogs.
复制标题
乙醇对大鼠和狗的低血钙作用。
作者：
T. Peng;C. Cooper;P. L. Munson
在大鼠和犬中，以2-8 g/kg bw的剂量经口给予乙醇，导致快速和持续的低钙血症。酒精后大鼠低钙血症的快速发作（30分钟内）和持续时间长（至少5小时）的特征与我们以前用乌拉坦观察到的相似。在对照实验中，向大鼠血清中添加酒精不会干扰钙测定的分析方法。此外，在研究的实验条件下，血液pH值或总血清蛋白没有发生变化。酒精的低钙作用不能用尿钙丢失增加来解释，因为这种作用在急性肾切除术后仍然存在，并且因为直接测量尿钙显示，在治疗后3小时内，乙醇降低而不是增加总尿钙。酒精引起的低钙血症与低磷血症无明显相关性。
Oral administration of ethyl alcohol in doses of 2-8 g/kg bw produced a rapid and sustained hypocalcemia in rats and dogs. The rapid onset (within 30 min) and the long duration (at least 5 hr) of hypocalcemia in rats after alcohol were characteristics similar to those we had observed previously with urethane. In control experiments, addition of alcohol to rat serum did not interfere with the analytical method for measurement of calcium. Furthermore, under the experimental conditions studied no changes in blood pH or total serum proteins occurred. The hypocalcemic effect of alcohol could not be explained by increased loss of urinary calcium, because the effect was retained after acute nephrectomy and because direct measurement of urine calcium revealed that ethanol decreased rather than increased total urinary calcium during a 3–hr time interval after treatment. The hypocalcemic action of alcohol differed from that of thyrocalcitonin; (a) the hypocalcemia caused by alcohol was not associated with hypophosp...