Family history of glaucoma in the primary and secondary open-angle glaucomas
Family history of glaucoma in the primary and secondary open-angle glaucomas
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DOI：
10.1007/s004170050278
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发表时间：
1999-07-01
影响因子：
2.7
通讯作者：
Jonas, JB
中科院分区：
文献类型：
--
作者：
Budde, WM;Jonas, JB
背景：本研究旨在评估原发性和继发性开角型脑胶质瘤阳性家族史的频率。患者及方法：该研究包括1176例慢性开角型青光眼患者，这些患者被分为继发性开角型青光眼[假性剥脱性青光眼（n=144）和色素性青光眼（n=61）]和原发性开角型青光眼（POAG; n=971）。POAG组分为非高度近视患者，无（“非高度近视POAG”; n=662）或有环形乳头旁萎缩（“年龄相关性萎缩性POAG”; n=168），高度近视POAG（n=35），局灶性正常眼压青光眼（n=106）。询问所有患者的家庭成员是否患有青光眼。结果如下：在POAG组中，青光眼阳性家族史的频率（总频率24.5%）随年龄的增长而显著降低，从50岁以下患者（n=240）的35.8%降至51 - 70岁患者（n=501）的25%，再降至70岁以上患者（n=230）的11.7%。与年龄匹配的非高度近视性POAG组相比，年龄相关性萎缩性POAG、局灶性正常眼压性青光眼、假性剥脱性青光眼和色素性青光眼的阳性青光眼家族史的总体频率无显著差异。高度近视的POAG有较低的，但没有显着降低，青光眼阳性家族史的频率（17.1%比26.9%）。结论：在POAG中，已知的青光眼阳性家族史的频率随着年龄的增加而降低。除了青少年发病的POAG相对较高，高度近视的POAG相对较低的频率已知的遗传，其他原发性和继发性开角型青光眼不shaw显着差异，在这个变量时，调整年龄。
Background: A study was carried out to evaluate the frequency of a positive family history in the primary and secondary open-angle glaucomas. Patients and methods: The study included 1176 patients with chronic open-angle glaucoma who were differentiated into secondary open-angle glaucoma [pseudoexfoliative glaucoma (n=144) and pigmentary glaucoma (n=61)], and primary open-angle glaucoma (POAG; n=971). The POAG group was divided into non-highly-myopic patients without ("'non-highly-myopic POAG"; n=662) or with circular parapapillary atrophy ("age-related atrophic POAG"; n=168), highly myopic POAG (n=35), and focal normal-pressure glaucoma (n=106). All patients were asked whether family members had glaucoma. Results: In the POAG group, frequency of a positive family history of glaucoma (overall frequency 24.5%) decreased significantly with age from 35.8% in patients (n=240) younger than 50 years, to 25% in patients (n=501) aged between 51 and 70 years and to 11.7% in patients (n=230) older than 70 years. The overall frequencies of a positive family history of glaucoma did not vary significantly between age-related atrophic POAG,focal normal-pressure glaucoma, pseudoexfoliative glaucoma, and pigmentary glaucoma, compared with age-matched groups of non-highly-myopic POAG. Highly myopic POAG had a lower, but not significantly lower, frequency of a positive family history of glaucoma (17.1% vs 26.9%).Conclusions: In POAG, frequency of a known positive family history of glaucoma decreases with increasing age. Apart from juvenile-onset POAG with a relatively high, and highly myopic POAG with a relatively low frequency of known heredity, other primary and secondary open-angle glaucomas do not shaw pronounced differences in this variable when adjusted for age.