What can genetic studies of left ventricular mass tell us?
What can genetic studies of left ventricular mass tell us?
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左心室质量的遗传学研究可以告诉我们什么？
DOI：
10.1161/circgenetics.111.961839
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Newton-Cheh,Christopher
中科院分区：
文献类型：
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作者：
Newton-Cheh,Christopher
左心室肥厚（LVH），无论是通过心电图、超声心动图还是尸检测量，都与心血管发病和死亡风险增加相关。 1, 2 尽管 LVH 与年龄、性别、体重指数和高血压等多种临床特征相关，但其影响及其方向根据 LVH 标准而有所不同。 3 家族内的聚集表明遗传因素具有遗传性，4 尽管最近一项大样本超声心动图左心室质量研究无法识别常见的遗传因素。 5 使用 LVH 治疗高血压可使其消退，从而降低心血管疾病的风险。 6 因此，尽管运动训练引起的 LVH 被认为是良性的，但它似乎是一个可改变的危险因素。因此，LVH 是一种具有多种定义的复杂特征，具有多种临床和遗传因素，并且在某些但并非所有情况下是可改变的危险因素。
Left ventricular hypertrophy (LVH), whether measured by electrocardiography, echocardiography, or at autopsy, is associated with increased risk of cardiovascular morbidity and mortality. 1, 2 Although LVH has been associated with several clinical characteristics such as age, sex, body mass index, and hypertension, the effects and their directionality have varied according to the criteria for LVH. 3 Aggregation within families suggests a heritable component due to genetics, 4 although a recent study of echocardiographic left ventricular mass in a large sample was unable to identify common genetic factors. 5 Treatment of hypertensives with LVH can lead to its regression and with it reduction in risk of cardiovascular disease. 6 Thus, it appears to be a modifiable risk factor, although LVH induced by exercise training is thought to be benign. Thus, LVH is a complex trait with diverse definitions, has multiple clinical and genetic contributors and is a modifiable risk factor in some but not all settings.