Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.
复制标题
通过注射分枝杆菌佐剂引起的关节炎和其他病变的研究。 V.影响皮肤和粘膜的变化。将实验过程与人类疾病的比较。
DOI：
10.1084/jem.113.3.485
复制
发表时间：
1961-03-01
期刊：
影响因子：
--
通讯作者：
SHARP JT
中科院分区：
文献类型：
--
作者：
PEARSON CM;WAKSMAN BH;SHARP JT
在大鼠实验中，弗氏佐剂诱导了一种全身性疾病。主要的临床和病理病变是四肢和尾部关节的关节炎、周炎、腱鞘炎和骨膜炎。在某些情况下，伴随关节炎的是其他特定的组织病变，包括虹膜环炎、无毛皮肤（耳、生殖器、足、尾）的结节性病变、短暂性皮疹、慢性皮肤病、泌尿生殖系统病变和腹泻。这些构成了一幅引人注目的、有特色的画面。关节炎通常先于其他病变，并与皮肤病一起表现出长期和波动的病程。不会发生内脏病变。组织学上，基本病变为淋巴细胞和组织细胞浸润，最初为血管周围浸润，随后弥散性加重。此外，在关节区域和阴茎海绵体，间充质细胞，尤其是成纤维细胞大量增生。纤维蛋白样坏死灶见于关节和结节性病变，关节的破坏性病变也很常见。这种组织病变的组合以前没有在实验病理学中描述过。这种实验性疾病与瑞特氏综合征、类风湿关节炎和某些其他人类疾病既有相似之处，也有不同之处。
A generalized disease is induced experimentally in the rat by administration of Freund's adjuvant. The primary clinical and pathologic lesions are arthritis, periarthritis, peritendinitis, and periostitis in the joints of the extremities and tail. Accompanying the arthritis in some cases, and never observed in its absence, are other specific tissue lesions including iridocyclitis, nodular lesions in the glabrous skin (ear, genitalia, feet, tail), transient rashes, a chronic skin disease, genitourinary lesions, and diarrhea. These make up a striking and characteristic picture. The arthritis usually precedes the other lesions and, together with the skin disease may show a prolonged and fluctuating course. Visceral lesions do not occur. Histologically, the basic lesion is a lymphocytic and histiocytic infiltration, initially perivascular and subsequently more disseminated. In addition, in the region of the joints and in the corpora cavernosa of the penis, there is extensive proliferation of mesenchymal cells, especially fibroblasts. Foci of fibrinoid necrosis are seen in the articular and nodular lesions, and destructive lesions of the joints are common. Such a combination of tissue lesions has not previously been described in experimental pathology. The experimental disease is shown to have both similarities to and differences from Reiter's syndrome, rheumatoid arthritis, and certain other disorders which occur in man.