COLLAGEN HETEROGENEITY IN HUMAN CARTILAGE - IDENTIFICATION OF SEVERAL NEW COLLAGEN CHAINS
COLLAGEN HETEROGENEITY IN HUMAN CARTILAGE - IDENTIFICATION OF SEVERAL NEW COLLAGEN CHAINS
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DOI：
10.1016/s0006-291x(79)80024-8
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发表时间：
1979-01-01
影响因子：
3.1
通讯作者：
HOLLISTER, DW
中科院分区：
文献类型：
--
作者：
BURGESON, RE;HOLLISTER, DW
正常人透明软骨除了含有α - α外，还含有5种可区分的胶原蛋白。1（II）型胶原链。描述了其中3种附加蛋白的特性。根据溶解度、电泳迁移率、离子交换和筛层析性能、氨基酸组成和溴化氰肽谱的标准，这些蛋白质中至少有2种，可能还有3种，在结构上是不同的胶原蛋白。链不同于先前报道的胶原链。脊椎动物胶原的分子异质性和至少9种不同的胶原链结构基因的存在暗示。
Normal human hyaline cartilages contain 5 distinguishable collagenous proteins in addition to, and different from, the .alpha.1(II) chain of Type II collagen. The characterization of 3 of these additional proteins was described. By the criteria of solubility, electrophoretic mobilities, ion-exchange and sieve chromatographic properties, amino acid compositions and cyanogen bromide peptide profiles, at least 2 of these proteins, and possibly the 3rd, are structurally distinct collagen .alpha. chains different from previously reported collagen chains. Further molecular heterogeneity of vertebrate collagens and the existence of at least 9 different structural genes for collagen chains were implied.