Sodium transport inhibitor from bovine hypothalamus.
Sodium transport inhibitor from bovine hypothalamus.
复制标题
来自牛下丘脑的钠转运抑制剂。
DOI：
10.1073/pnas.76.9.4658
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发表时间：
1979
影响因子：
11.1
通讯作者：
J. Sancho
中科院分区：
文献类型：
--
作者：
G. T. Haupert;J. Sancho
从牛下丘脑经酸/丙酮提取和凝胶过滤制备了一种具有钠转运抑制特性的低分子量碱性非肽因子。通过离子交换色谱实现浓缩和部分纯化。该物质抑制Na+主动跨膜转运，抑制哇巴因与青蛙膀胱的结合，并直接抑制肾Na+，K+-ATP酶。因此，这种物质具有下丘脑来源的利钠因子的假定特征。
A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+,K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.