A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers
A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers
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DOI：
10.1016/j.jinf.2009.05.008
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发表时间：
2009-07-01
影响因子：
28.2
通讯作者：
O'Brien, Daniel P.
中科院分区：
文献类型：
--
作者：
Swaminathan, Ashwin;Torresi, Joseph;O'Brien, Daniel P.
目的：传染性胃肠道疾病（IGD）是一个重要的原因，发病率在返回的国际旅行者。本研究旨在阐明与IGD表现相关的宿主和旅行特征，并描述由地理区域采集和旅行原因引起的病原体的广谱性。方法：我们分析了1996年9月至2005年12月期间在全球范围内向GeoSentinet监测网络站点报告的患病、返回的国际旅行者的人口统计学、临床和微生物学数据。共分析了25，867名返回的旅行者，其中7442名（29%）患者共有8273例IGD诊断。多变量分析表明，IGD表现与女性性别（OR：1.11; p = 0.001）、年龄较小组、参加旅行前医疗预约（OR：1.28; p < 0.0001）和旅游原因旅行显著相关。长期旅行（> 28天）与塔风险相关（OR：0.93; p = 0.04）。在分离的2902种临床显著病原体中，65%为寄生虫，31%为细菌，3%为病毒。介绍IGD的特定病原体变化显着依赖于地理区域最近的旅行，和原因travel.Conclusions：主机特性，旅行地区和类别的旅客，显着影响的相对可能性提出了广泛的病原体特异性IGD。(c)2009年，英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: Infectious gastrointestinal disease (IGD) is a significant cause of morbidity in returned international travellers. This study aims to elucidate host and travel characteristics associated with IGD presentation, and describe the broad spectrum of aetiological pathogens responsible by geographic region of acquisition and reason for travel.Methods: We analyzed demographic, clinical and microbiological data recorded for ill, returned international travellers presenting to GeoSentinet Surveillance Network sites globally during the period September 1996-December 2005.Results: A total of 25,867 returned travellers were analyzed, of whom 7442 (29%) patients had a total of 8273 IGD diagnoses. Multivariate analysis demonstrated that IGD presentation was associated significantly with female sex (OR: 1.11; p = 0.001); younger age group; attending a pre-travel medical appointment (OR: 1.28; p < 0.0001); and travelling for the reason of tourism. Travelling for longer periods (> 28 days) was associated with tower risk (OR: 0.93; p = 0.04). Of the 2902 clinically significant pathogens isolated, 65% were parasitic, 31% bacterial and 3% viral. Presentation of IGD by specific pathogen varied markedly dependent on geographic region of recent travel, and reason for travel.Conclusions: Host characteristics, region of travel and category of traveller, significantly impact on the relative likelihood of presenting with a broad range of pathogen-specific IGD. (c) 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.