Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer
Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer
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DOI：
10.1093/jnci/djj305
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发表时间：
2006-08-16
影响因子：
10.3
通讯作者：
Earle, Craig C.
中科院分区：
文献类型：
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作者：
Hassett, Michael J.;O'Malley, A. James;Earle, Craig C.
背景在临床试验之外接受乳腺癌化疗的年轻女性所经历的严重不良反应的数量、性质和费用尚不清楚。研究方法：从1998年1月至2002年12月雇主提供的健康保险个人的医疗索赔数据库中，我们确定了12239名年龄在63岁或63岁以下的女性新诊断的乳腺癌，其中4075人在最初的乳腺癌诊断后的12个月内接受化疗，8164人没有。确定了8种化疗相关不良反应的诊断代码。对两组女性的所有原因的住院总人数、因通常与化疗相关的不良反应而住院或急诊的人数以及医疗保健费用进行了比较。所有统计检验均为双侧检验。结果如下：接受化疗的女性比未接受化疗的女性更有可能因各种原因住院或去急诊室（61%对42%;平均差异= 19%，95%置信区间[CI]=16.7%至21.3%，P
Background. The number, nature, and costs of serious adverse effects experienced by younger women receiving chemotherapy for breast cancer outside of clinical trials are unknown. Methods: From a database of medical claims made by individuals with employer-provided health insurance between January 1998 and December 2002, we identified 12239 women 63 years of age or younger with newly diagnosed breast cancer, of whom 4075 received chemotherapy during the 12 months after the initial breast cancer diagnosis and 8164 did not. Diagnostic codes for eight chemotherapy-related adverse effects were identified. Total hospitalizations for all causes, hospitalizations or emergency room visits for adverse effects that are typically related to chemotherapy, and health care expenditures were compared between the two groups of women. All statistical tests were two-sided. Results: Women who received chemotherapy were more likely than those who did not to be hospitalized or to visit the emergency room for all causes (61% versus 42%; mean difference=19%, 95% confidence interval [CI]=16.7% to 21.3%, P