Expression and function of CXCR7 in the mouse forebrain
Expression and function of CXCR7 in the mouse forebrain
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DOI：
10.1016/j.jneuroim.2010.05.011
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发表时间：
2010-07-27
影响因子：
3.3
通讯作者：
Cremer, Harold
中科院分区：
文献类型：
--
作者：
Tiveron, Marie-Catherine;Boutin, Camille;Cremer, Harold
趋化因子CXCL 12/CXCR 4信号系统对于发育中的前脑中神经元迁移的调节是重要的。特别是它是至关重要的正确分布的Cajal-Retzius细胞和迁移的皮质中间神经元。在这里，我们研究了CXCR 7的表达，CXCL 12的第二个受体，与CXCR 4相比。我们发现，在上述引用的细胞群中，两种受体表达的变化与其迁移行为的主要变化一致。此外，我们表明，出生后产生的嗅觉中间神经元前体表达CXCR 7，但不CXCR 4，它们在吻侧迁移流中的分布受到CXCR 7下调的影响。这表明CXCR 7参与神经元细胞迁移，并表明CXCR 7独立于CXCR 4作为CXCL 12信号传导的介体的可能作用。(C)2010爱思唯尔有限公司版权所有。
The chemokine CXCL12/CXCR4 signaling system is important for the regulation of neuron migration in the developing forebrain. In particular it is crucial for correct distribution of Cajal-Retzius cells and migration of cortical interneurons. Here we investigated the expression of CXCR7, the second receptor for CXCL12, in comparison to CXCR4. We found that shifts in the expression of both receptors in the above cited cell populations coincide with major changes in their migratory behavior. Furthermore, we demonstrated that postnatally generated olfactory interneuron precursors express CXCR7 but not CXCR4 and that their distribution in the rostral migratory stream is affected by CXCR7 downregulation. This suggests an involvement of CXCR7 in neuronal cell migration and indicates a possible action of CXCR7 independently of CXCR4 as a mediator of CXCL12 signaling. (C) 2010 Elsevier B.V. All rights reserved.