Enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers
Enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers
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DOI：
10.1021/ja067501q
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发表时间：
2007-02-07
影响因子：
15
通讯作者：
Paquin, Jean-Francois
中科院分区：
文献类型：
--
作者：
Belanger, Etienne;Cantin, Katy;Paquin, Jean-Francois
报道了钯催化的含氟硅烯醇醚的烯丙基化反应。该反应提供了一种由非手性氟化前体制备烯丙基化叔氟酮的立体选择性和有效的方法。可使用多种环硅烯醇醚，目标产物的产率为52 - 93%，对映体过量为83 - 95%ee。
An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary -fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.