The Correlation between Aqueous Vascular Endothelial Growth Factor Level and Clinical Activity in Neovascular Age-Related Macular Degeneration.
The Correlation between Aqueous Vascular Endothelial Growth Factor Level and Clinical Activity in Neovascular Age-Related Macular Degeneration.
复制标题
水性血管内皮生长因子水平与新生血管性年龄相关性黄斑变性临床活动之间的相关性。
DOI：
10.1097/iae.0000000000002790
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ohji M
中科院分区：
文献类型：
--
作者：
Ichiyama Y;Sawada T;Sawada O;Ito Y;Kakinoki M;Obata S;Saishin Y;Ohji M
目的：目前的研究的目的是探讨血管内皮生长因子（VEGF）和新生血管性年龄相关性黄斑变性的临床活动的预处理水的水平之间的相关性。方法：与新生血管性年龄相关性黄斑变性玻璃体内注射雷珠单抗治疗，并随后为12个月的患者被列入本研究。治疗方案包括连续三个月玻璃体内注射雷珠单抗（负荷治疗），然后是促新生（PRN）治疗方案。采用酶联免疫吸附测定法测定房水中VEGF的水平，获得的前一个玻璃体内雷珠单抗injections.Results：64眼的64例患者被列入本研究。12个月内玻璃体内注射雷珠单抗的平均次数为4.6±1.4次，17只眼在负荷治疗后无复发。负荷治疗后复发眼的平均房水VEGF水平显著高于无复发眼（分别为107.6和83.8 pg/mL; P= 0.04），并且在负荷治疗后3个月内复发的眼睛中显著高于其他眼睛结论：新生血管性年龄相关性黄斑变性患者治疗前房水VEGF水平与复发可能性显著相关。检测治疗前房水VEGF水平可能有助于确定新生血管性年龄相关性黄斑变性患者的最佳治疗方案。
Purpose:The aim of the current study was to investigate the correlation between the pretreatment aqueous level of vascular endothelial growth factor (VEGF) and clinical activity in neovascular age-related macular degeneration.Methods:Patients with neovascular age-related macular degeneration treated by intravitreal ranibizumab injections and followed for 12 months were included in the current study. The treatment regimen consisted of three consecutive monthly intravitreal ranibizumab injections (loading treatment) followed by a pro re nata (PRN) treatment regimen. The aqueous VEGF levels were measured by enzyme-linked immunosorbent assay using aqueous humor samples obtained just before the first intravitreal ranibizumab injections.Results:Sixty-four eyes of 64 patients were included in the current study. The mean number of intravitreal ranibizumab injections during 12 months was 4.6±1.4, and 17 eyes had no recurrence after loading treatment. The mean aqueous VEGF level was significantly higher in eyes with recurrence after loading treatment than in eyes without recurrence (107.6 vs. 83.8 pg/mL, respectively; P= 0.04) and significantly higher in eyes with recurrence within 3 months after loading treatment than in other eyes (114.9 vs. 86.7 pg/mL, respectively; P< 0.01).Conclusion:Pretreatment aqueous VEGF level was significantly correlated with the likelihood of recurrence in neovascular age-related macular degeneration. The measurement of pretreatment aqueous VEGF level may be useful to determine the best treatment options for patients with neovascular age-related macular degeneration.