Probing the Red Blood Cells Aggregating Force With Optical Tweezers
Probing the Red Blood Cells Aggregating Force With Optical Tweezers
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DOI：
10.1109/jstqe.2015.2477396
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发表时间：
2016-05-01
影响因子：
4.9
通讯作者：
Meglinski, Igor
中科院分区：
文献类型：
--
作者：
Lee, Kisung;Danilina, Anna V.;Meglinski, Igor
红细胞（RBC）聚集作为血液微循环的决定因素，是当前基础科学和临床研究的热点。因此，测量和评估人类个体或实验动物在不同生理条件下的红细胞聚集特性（可聚集性）和聚集状态是一个重要的问题。在本文中，为了评估RBC相互作用的动力学，使用光学镊子探测在RBC双偶形成或破坏过程中的力。我们发现，在自体血浆中，红细胞聚集力和分解力具有不同的绝对值，相应的约为2-4 pN和几十皮牛顿。我们推测，在血浆中，红细胞聚集和分解过程有不同的驱动力。
The red blood cells (RBC) aggregation is of current basic science and clinical interest, as a determinant of blood microcirculation. Thus, the measurement and assessment of the RBC aggregation property (aggregability) and aggregation state at different physiologic conditions of a human individual or laboratory animal are an important issue. In this paper, in order to assess the dynamics of RBC interaction, optical tweezers were used to probe the forces during the RBC doublet formation or disruption. We show that in autologous plasma, RBC aggregating and disaggregating forces have different absolute values, ca 2-4 pN and dozens of piconewton, correspondingly. We speculate that in plasma, RBC aggregation and disaggregation processes have different driving forces.