Monoderm bacteria: the new frontier for type IV pilus biology.
Monoderm bacteria: the new frontier for type IV pilus biology.
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Monoderm 细菌：IV 型菌毛生物学的新领域。
DOI：
10.1111/mmi.14397
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发表时间：
2019
影响因子：
3.6
通讯作者：
Pelicic V
中科院分区：
文献类型：
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作者：
Pelicic V
在细菌皮利的多样性世界中，IV型皮利（Tfp）是独特的，原因有两个：它们的多功能性和普遍性。后一个特征提供了一种非凡的可能性，即在进化上遥远的物种中进行比较研究，以改善我们对TFP生物学的零碎理解。令人遗憾的是，这种潜力在很大程度上尚未开发，因为20年来，Tfp仅在双胚层细菌中被表征。然而，最近的研究TFP在单胚层动物已经开始缩小差距，揭示了许多有趣的共性和一些显着的差异，扩大前沿的知识TFP生物学。在这里，我回顾了目前的技术水平的TFP领域的单胚层细菌和讨论所产生的影响，我们一般的理解这些广泛的丝状纳米机器的组装和功能。
In the diverse world of bacterial pili, type IV pili (Tfp) are unique for two reasons: their multifunctionality and ubiquity. This latter feature offers an extraordinary possibility, that is, to perform comparative studies in evolutionarily distant species in order to improve our fragmentary understanding of Tfp biology. Regrettably, such potential has remained largely untapped, because, for 20 years, Tfp have only been characterised in diderm bacteria. However, recent studies of Tfp in monoderms have started closing the gap, revealing many interesting commonalities and a few significant differences, extending the frontiers of knowledge of Tfp biology. Here, I review the current state of the art of the Tfp field in monoderm bacteria and discuss resulting implications for our general understanding of the assembly and function of these widespread filamentous nanomachines.