The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala
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5-HTTLPR 的长等位基因而非短等位基因使汉族人容易焦虑，并减少前额皮质和杏仁核之间的连接
DOI：
10.1007/s12264-013-1299-x
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发表时间：
2013-02-01
影响因子：
5.6
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Long, Haixia;Liu, Bing;Jiang, Tianzi
血清素转运体基因的短等位基因与高加索人患焦虑和抑郁症的较高风险相关，但在亚洲人中这种关联仍不明确。在此，我们通过行为学和多模态磁共振成像方法在一大组健康的汉族参与者（n = 233）中研究了这一问题。与在高加索人中的发现相反，我们发现长等位基因（L）携带者有更高的焦虑分数。在另一组有明显抑郁或焦虑水平的人群（n = 64）中，L等位基因频率也显著更高。在健康参与者中，L携带者的杏仁核和前额叶皮质（PFC）之间的功能和解剖连接减弱，这与焦虑或抑郁分数相关。我们的研究结果表明，与高加索人相反，在中国汉族参与者中，L等位基因使个体易患焦虑或抑郁症，并削弱了PFC和杏仁核之间自上而下的情绪控制。因此，在基因相关研究及其潜在临床应用中应考虑种族背景。
The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n= 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n= 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in generelated studies and their potential clinical applications.