The importance of TSLP in allergic disease and its role as a potential therapeutic target.
The importance of TSLP in allergic disease and its role as a potential therapeutic target.
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DOI：
10.1586/1744666x.2014.967684
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发表时间：
2014-11
影响因子：
4.4
通讯作者：
Spergel J
中科院分区：
文献类型：
--
作者：
Cianferoni A;Spergel J
胸腺基质淋巴生成素（Thymic stromal lymphoopoietin， TSLP）是一种类似于IL- 7的上皮源性细胞因子，其基因位于染色体5q22.1上，通过TSLP受体（TSLP- r）发挥生物学功能。TSLP主要由皮肤、肠道和肺等屏障表面的上皮细胞对危险信号作出反应而表达。自1994年克隆以来，越来越多的证据表明，TSLP对抗原提呈细胞和造血细胞的成熟至关重要。TSLP基因变异及其失调表达与特应性皮炎、哮喘、过敏性鼻炎和嗜酸性粒细胞性食管炎等特应性疾病有关。
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine similar to IL- 7, whose gene is located on chromosome 5q22.1 and it exerts its biological function through the TSLP-Receptor (TSLP-R). TSLP is expressed primarily by epithelial cells at barrier surfaces such as the skin, gut and lung in response to danger signals. Since it was cloned in 1994, there has been accumulating evidence that TSLP is crucial for the maturation of antigen presenting cells and hematopoietic cells. TSLP genetic variants and its dysregulated expression have been linked to atopic diseases such as atopic dermatitis, asthma, allergic rhinitis and eosinophilic esophagitis.