Effect of ultrasound amplitude and frequency on nanoparticle diffusion in an agarose hydrogel
Effect of ultrasound amplitude and frequency on nanoparticle diffusion in an agarose hydrogel
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DOI：
10.1121/10.0012972
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发表时间：
2022-07-01
影响因子：
2.4
通讯作者：
Wu, Junru
中科院分区：
文献类型：
--
作者：
Karki, Alina;Marshall, Jeffrey S.;Wu, Junru
人们观察到，纳米颗粒在多孔介质(如水凝胶)中暴露在低强度超声波下，可以显著提高颗粒渗透率。增强纳米粒子的渗透性是影响生物被膜缓解和人体组织靶向给药等应用的关键问题。本研究利用荧光成像技术，对超声振幅和频率对不同直径纳米颗粒在琼脂糖凝胶中扩散的影响进行了详细的实验测量，琼脂糖凝胶通常被用作生物膜和生物组织的模拟剂。我们证明了声学增强是通过振荡扩散现象发生的，在振荡扩散现象中，振荡流和粒子与水凝胶蛋白质相互作用的随机阻碍相结合，导致了粒子的随机随机行走。利用测得的声扩散系数随幅度和频率的变化，验证了以前基于连续时间随机游走方法的振荡扩散统计理论。(C)2022年美国声学学会。
Exposure of nanoparticles in a porous medium, such as a hydrogel, to low-intensity ultrasound has been observed to dramatically enhance particle penetration rate. Enhancement of nanoparticle penetration is a key issue affecting applications such as biofilm mitigation and targeted drug delivery in human tissue. The current study used fluorescent imaging to obtain detailed experimental measurements of the effect of ultrasound amplitude and frequency on diffusion of nanoparticles of different diameters in an agarose hydrogel, which is often used as a simulant for biofilms and biological tissues. We demonstrate that the acoustic enhancement occurs via the phenomenon of oscillatory diffusion, in which a combination of an oscillatory flow together with random hindering of the particles by interaction with hydrogel proteins induces a stochastic random walk of the particles. The measured variation of acoustic diffusion coefficients with amplitude and frequency were used to validate a previous statistical theory of oscillatory diffusion based on the continuous time random walk approach. (C) 2022 Acoustical Society of America.