Anticancer activity of polyoxomolybdate.
Anticancer activity of polyoxomolybdate.
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DOI：
10.1016/j.biopha.2006.06.018
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发表时间：
2006-08
期刊：
影响因子：
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通讯作者：
H. Yanagie;A. Ogata;S. Mitsui;T. Hisa;T. Yamase;M. Eriguchi
中科院分区：
文献类型：
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作者：
H. Yanagie;A. Ogata;S. Mitsui;T. Hisa;T. Yamase;M. Eriguchi
研究了多金属氧酸盐作为金属氧化物的离散簇阴离子在抗癌方面的医学应用。[NH3Pri]6[Mo7O24]·3H2O （PM-8）已被认为是一种重要的抗肿瘤多氧钼酸盐。PM-8已显示出对几种肿瘤的生长抑制作用，如Co-4，人结肠癌，MX-1，人乳腺癌，OAT，人肺癌。PM-8对荷瘤小鼠的MKN-45人胃癌具有抑制肿瘤生长的作用。PM-8对AsPC-1细胞生长的抑制作用依赖于剂量，表现为DNA阶梯形成和DNA断裂，Hoechst染色阳性提示凋亡。经流式细胞术分析，PM-8处理48 h、72 h后细胞凋亡率分别为35%、57%。PM-8的抗肿瘤活性之一来自于细胞凋亡通路的激活。多氧钼酸盐有望成为一种新型的抗肿瘤药物，特别是治疗临床治疗困难的肿瘤。
Anticancer polyoxomolybdates have been investigated for medical application of polyoxometalates as discrete cluster anions of metal oxides. [NH3Pri]6[Mo7O24]·3H2O (PM-8) has been recognized as one of significant antitumoral polyoxomolybdates. PM-8 had shown the growth suppression against several tumors, for examples, Co-4, human colon cancer, MX-1, human breast cancer, and OAT, human lung cancer. PM-8 showed the tumor growth suppression for MKN-45 human gastric cancer in tumor bearing mice. PM-8 inhibited the cell growth of AsPC-1 which depended on the dose with showing DNA ladder formation and DNA fragmentation, and positive Hoechst staining indicating apoptosis. The ratio of apoptotic cells on flow cytometry analysis were 35%, and 57% with treatment of PM-8 after 48, and 72 h, respectively. One of the anti-tumor activity of PM-8 result from the activation of apoptotic pathway. It is thought that polyoxomolybdates will be applied as a novel anti-tumor agent especially against cancers which are difficult to be treated clinically.