Gene expression profiling in stroke: relevance of blood-brain interaction.
Gene expression profiling in stroke: relevance of blood-brain interaction.
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DOI：
10.1016/j.coph.2015.10.004
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发表时间：
2016-02
影响因子：
4
通讯作者：
Barr TL
中科院分区：
文献类型：
--
作者：
Asano S;Chantler PD;Barr TL
生物标记物分析被用于确定中风的诊断和预后候选对象。临床和临床前生物标记物数据表明，循环免疫反应的改变可能阐明了中风康复的机制。然而，外周血液生物标记物特征(S)如何与中风后的脑特征相关尚不清楚。数据显示，中性粒细胞淋巴细胞比率(NLR)可以预测中风的结局。中性粒细胞释放精氨酸酶1(ARG1)，导致外周血中T淋巴细胞的抑制。有趣的是，细胞对中风的反应可能对已知的生物标记物特征有影响。相反，临床前证据表明，小胶质细胞中ARG1的上调是M2巨噬细胞的标志，并可能影响神经保护。比较临床和临床前研究为探索中风患者血液和脑生物标记物相互作用的分子机制创造了机会。
Biomarker profiling is utilized to identify diagnostic and prognostic candidates for stroke. Clinical and preclinical biomarker data suggest altered circulating immune responses may illuminate the mechanisms of stroke recovery. However, how peripheral blood biomarker profile(s) relate to brain profiles following stroke is unknown. Data show that neutrophil lymphocyte ratio (NLR) predicts stroke outcome. Neutrophils release Arginase 1 (ARG1) resulting in T lymphocyte suppression in peripheral blood. Interestingly, cellular response to stroke may have implications for known biomarker profiles. Conversely, preclinical evidence suggests that upregulation of ARG1 in microglia is a marker of M2 macrophages and may influence neuroprotection. Comparing clinical and preclinical studies creates opportunities to explore the molecular mechanisms of blood and brain biomarker interactions in stroke.