The inheritance of centromere identity.
The inheritance of centromere identity.
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DOI：
10.1080/23723556.2016.1188226
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发表时间：
2016-07
影响因子：
2.1
通讯作者：
Kitagawa K
中科院分区：
文献类型：
--
作者：
Niikura Y;Kitagawa R;Kitagawa K
CENP-A（着丝粒蛋白A）是一种组蛋白H3变体，其表观遗传决定了着丝粒的位置，但其着丝粒遗传机制尚不清楚。我们认为，CENP-A泛素化，这是通过细胞分裂轮之间的二聚化遗传，是一个候选人的着丝粒身份的表观遗传标记。
CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A ubiquitylation, which is inherited through dimerization between rounds of cell division, is a candidate for the epigenetic mark of centromere identity.