VITAMIN-B6 DEFICIENCY IMPAIRS INTERLEUKIN-2 PRODUCTION AND LYMPHOCYTE-PROLIFERATION IN ELDERLY ADULTS
VITAMIN-B6 DEFICIENCY IMPAIRS INTERLEUKIN-2 PRODUCTION AND LYMPHOCYTE-PROLIFERATION IN ELDERLY ADULTS
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DOI：
10.1093/ajcn/53.5.1275
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发表时间：
1991-05-01
影响因子：
7.1
通讯作者：
GERSHOFF, SN
中科院分区：
文献类型：
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作者：
MEYDANI, SN;RIBAYAMERCADO, JD;GERSHOFF, SN
本文研究了8名健康老年人维生素B-6缺乏对免疫应答的影响。 该方案包括5天的基线（BL）期;小于或等于20天的维生素B-6消耗期;三个阶段的维生素B-6补充，每个阶段持续21天;和4天的最终阶段。 在研究的不同阶段期间摄入的维生素B-6的量为3.00、15.00、22.50和33.75-mu-g.kg body wt-1。D-1，分别。 在最后阶段，受试者摄入50 mg维生素B-6/d。 在每个阶段结束时采集空腹血液。 维生素B-6耗竭显著降低淋巴细胞的百分比和总数、外周血淋巴细胞对T细胞和B细胞有丝分裂原的促有丝分裂反应以及白细胞介素2的产生。 在第三个维生素B-6补充期后，这些指数恢复到BL值，此时女性维生素B-6总摄入量为1.90 +/- 0.18 mg/d，男性为2.88 +/- 0.17 mg/d。 维生素B-6缺乏损害健康老年人细胞介导免疫的体外指标 这种损害可通过补充维生素B-6而逆转。
The effect of vitamin B-6 deficiency on immune response was studied in eight healthy elderly adults. The protocol consisted of a 5-d baseline (BL) period; a vitamin B-6-depletion period of less-than-or-equal-to 20 d; three stages of vitamin B-6-repletion, each lasting 21 d; and a 4-d final phase. The amounts of vitamin B-6 ingested during the different phases of the study were 3.00, 15.00, 22.50, and 33.75-mu-g.kg body wt-1. d-1, respectively. During the final phase the subjects ingested 50 mg vitamin B-6/d. Fasting blood was collected at the end of each period. Vitamin B-6 depletion significantly decreased percentage and total number of lymphocytes, mitogenic responses of peripheral blood lymphocytes to T- and B-cell mitogens, and interleukin 2 production. These indices returned to BL values after the third vitamin B-6-repletion period, when the total vitamin B-6 intakes were 1.90 +/- 0.18 mg/d for women and 2.88 +/- 0.17 mg/d for men. Vitamin B-6 deficiency impairs in vitro indices of cell-mediated immunity in healthy elderly adults. This impairment is reversible by vitamin B-6 repletion.