Patterns in adolescent cannabis use predict the onset and symptom structure of schizophrenia-spectrum disorder.
Patterns in adolescent cannabis use predict the onset and symptom structure of schizophrenia-spectrum disorder.
复制标题
青少年大麻使用模式可以预测精神分裂症谱系障碍的发病和症状结构。
DOI：
10.1016/j.schres.2018.01.008
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发表时间：
2018
影响因子：
4.5
通讯作者：
Manschreck,TC
中科院分区：
文献类型：
--
作者：
Shahzade,C;Chun,J;DeLisi,LE;Manschreck,TC
这项研究调查了青少年大麻使用作为精神分裂症谱系障碍（SSD）的危险因素。早期大麻使用的动机和由此产生的使用模式进行了检查，同时临床措施SSD发病和adminatology.Participants（N = 178）被招募为两个样本，1：健康对照（HC）与大麻的使用，2：精神分裂症患者（SSD）与大麻的使用。参与者和家庭线人的结构化访谈被用来获得诊断和biographical information.Factor分析报告的动机开始使用大麻产生四个组，镇静，刺激，社会压力，娱乐。回归分析显示，这些群体和SSD之间的显着关系。最值得注意的是，原因组因子评分预测SSD风险以及典型症状的严重程度。研究结果还表明，这些因素遵循一个层次结构，这解释了他们的相对参与增加SSD risk.We建议，青少年大麻的使用都加快了发病和放大SSD的严重程度。作为回应，我们提出了一个模型，用于识别高危人群，预测SSD的发病和严重程度，并可能减轻相关的精神障碍。
This study investigated adolescent cannabis use as a risk factor for schizophrenia spectrum disorder (SSD). Motives for early cannabis use and resulting usage patterns were examined alongside clinical measures of SSD onset and symptomatology.Participants (N = 178) were recruited for two samples, 1: healthy controls (HC) with cannabis use, 2: schizophrenia patients (SSD) with cannabis use. Structured interviews of participants and family informants were used to obtain diagnostic and biographical information.Factor-analysis of reported motives for initiating cannabis use produced four groups; sedation, stimulation, social pressure, and recreation. Regression analyses revealed significant relationships between these groups and SSD. Most notably, reason group factor scores predict SSD risk as well as schizotypal symptom severity. Findings also indicate that these factors follow a hierarchical structure, which explains their relative involvement in increased SSD risk.We suggest that adolescent cannabis use both hastens the onset and amplifies the severity of SSD. In response we propose a model for identifying at risk individuals, predicting the onset and severity of SSD, and potentially mitigating the associated psychiatric impairments.