Concentrations of dioxin 20 years after Seveso
Concentrations of dioxin 20 years after Seveso
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DOI：
10.1016/s0140-6736(97)24025-0
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发表时间：
1997-06-21
期刊：
影响因子：
168.9
通讯作者：
Caporaso, N
中科院分区：
文献类型：
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作者：
Landi, MT;Needham, LL;Caporaso, N
Mt Landi，LL Needham，G Lucier，P Mocarelli，PA Bertazzi，N Caporaso或报告男女体重下降。在B区妇女的生殖变量研究中，只有口服避孕药与较低的TCDD浓度显著相关(从未使用过避孕药的n=13，GM=23.4；曾经使用过的n=13，GM=13.2，p=0.05，t检验)。在对B区个体的多变量分析中，我们还检查了性别、年龄、吸烟状况、BMI和事故期间食用的食物的影响。性别、离事故现场的距离和肉类消费与TCDD浓度显著相关(p=0.0002、p=0.02和p=0.05)。据我们所知，在接触TCDD的人群中，以前没有报告过性别差异，可能是因为许多群体主要由因职业或服兵役而暴露的男性组成，但一项包括女性在内的研究报告了类似的结果。4女性TCDD浓度升高可能是由于代谢或排泄的变化，或由于体内脂肪或激素相关因素的差异。在塞维索，癌症发生的性别差异也有报道。1记录的TCDD浓度引起了人们对妇女及其后代的不良生殖、发育和癌症后果的关注。
MT Landi, LL Needham, G Lucier, P Mocarelli, PA Bertazzi, N Caporaso or reported weight loss for each sex. Among the reproductive variables studies in women of zone B, only oral contraceptive use was significantly associated with lower TCDD concentrations (never users n= 13, GM= 23· 4; ever users n= 13, GM= 13· 2, p= 0· 05, t-test). In a multivariate analysis of individuals in zone B, we also examined the effect of sex, age, smoking status, BMI, and food consumed during the accident period. Sex, distance from the accident site, and meat consumption were significantly associated with TCDD concentration (p= 0· 0002, p= 0· 02, and p= 0· 05, respectively). As far as we know, a gender difference has not been previously reported in TCDD-exposed populations, perhaps because many groups have consisted mostly of men exposed as a result of their occupation or military service, but one study that included women has reported similar findings. 4 Increased TCDD concentrations in women may be due to variation in metabolism or elimination, or to differences in body fat or hormone-related factors. Gender differences in cancer occurrence have also been reported in Seveso. 1 The recorded TCDD concentrations raise concern about adverse reproductive, developmental, and cancer outcomes in women and their offspring.