Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review.
Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review.
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DOI：
10.1016/j.ijwd.2018.05.001
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发表时间：
2018-12-01
影响因子：
--
通讯作者：
Cacciapuoti, S
中科院分区：
文献类型：
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作者：
Fabbrocini, G;Cantelli, M;Cacciapuoti, S
女性型脱发（FPHL）是女性最常见的脱发形式。受影响的妇女可能会经历心理困扰和社会功能受损。早期诊断和开始治疗是可取的，因为治疗比刺激再生更能有效地避免脱发的进展。通常，仅通过回顾患者的病史和体检即可确诊 FPHL。头皮活检具有诊断作用，但通常不是必需的。对于有雄激素过多症迹象的女性，应进行卵巢或肾上腺疾病的检查。 FPHL 的治疗被一些神话所掩盖。 FPHL 治疗的目的可能有两个：逆转或稳定毛囊微型化的过程。女性轻至中度 FPHL 可以通过口服抗雄激素疗法（醋酸环丙孕酮和螺内酯）和/或局部米诺地尔治疗，在许多情况下可获得良好效果。如果使用得当，现有的药物治疗可以阻止大多数轻至中度 FPHL 患者的疾病进展并逆转其小型化。对于某些严重 FPHL 病例，可以考虑毛发系统和手术。
Female pattern hair loss (FPHL) is the most common form of alopecia in women. Affected women may experience psychological distress and impaired social functioning. Early diagnosis and initiation of treatment are desirable because treatments are more effective to avoid the progression of hair loss than stimulating regrowth. Typically, a diagnosis of FPHL can be confirmed by review of a patient's medical history and a physical examination alone. Testing a scalp biopsy is diagnostic but usually not required. In women with signs of hyperandrogenism, an investigation for ovarian or adrenal disorders should be performed. Treatment for FPHL is obscured by myths. The aim of FPHL treatment could be two-fold: Reverse or stabilize the process of hair follicle miniaturization. Mild-to-moderate FPHL in women can be treated with oral antiandrogen therapies (cyproterone acetate and spironolactone) and/or topical minoxidil with good results in many cases. If used correctly, available medical treatments arrest the progression of the disease and reverse miniaturization in most patients with mild-to-moderate FPHL. Hair systems and surgery may be considered for selected cases of severe FPHL.