Adaptive behavior of neighboring neurons during adaptation-induced plasticity of orientation tuning in VI.
Adaptive behavior of neighboring neurons during adaptation-induced plasticity of orientation tuning in VI.
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DOI：
10.1186/1471-2202-10-147
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发表时间：
2009-12-14
期刊：
影响因子：
2.4
通讯作者：
Molotchnikoff S
中科院分区：
文献类型：
--
作者：
Nemri A;Ghisovan N;Shumikhina S;Molotchnikoff S
感觉神经元在长时间暴露于适当的刺激（适应）后会显示其反应特性的瞬时变化。在成年猫初级视皮层中，方向选择神经元在适应非偏好方向后会改变其偏好方向。这些变化的方向，朝向（吸引）或远离（排斥）适配器主要取决于适应持续时间。一个神经元的适应性行为与其邻近神经元的适应性行为之间的关系尚不清楚。在这里，我们发现，在大多数情况下（75%），细胞的首选方向移动到与其邻居相同的方向。我们还发现，细胞与其邻居（25%）不同地移动优选取向显示出三个有趣的特性：（i）绝对移动幅度的较大方差，（ii）更宽的调谐带宽和（iii）细胞簇之间的优选取向的较大范围。V1神经元的几个响应特性取决于它们在皮层方向图中的位置。我们的研究结果表明，记录网站的吸引力和排斥性的变化后，适应可能位于靠近等取向域边界或风车中心。事实上，这些区域的当地投入的方向分布更加多样化，这可以解释上述三个特性。另一方面，所有细胞在相同方向上移动其优选取向的位点可以位于等取向域内。我们的研究结果表明，方向和幅度的方向偏好转移V1依赖于在方向图内的位置。这种各向异性的适应诱导的可塑性，相当于视觉皮层本身，可能有重要的影响，我们的理解视觉适应的心理物理水平。
Sensory neurons display transient changes of their response properties following prolonged exposure to an appropriate stimulus (adaptation). In adult cat primary visual cortex, orientation-selective neurons shift their preferred orientation after being adapted to a non-preferred orientation. The direction of those shifts, towards (attractive) or away (repulsive) from the adapter depends mostly on adaptation duration. How the adaptive behavior of a neuron is related to that of its neighbors remains unclear. Here we show that in most cases (75%), cells shift their preferred orientation in the same direction as their neighbors. We also found that cells shifting preferred orientation differently from their neighbors (25%) display three interesting properties: (i) larger variance of absolute shift amplitude, (ii) wider tuning bandwidth and (iii) larger range of preferred orientations among the cluster of cells. Several response properties of V1 neurons depend on their location within the cortical orientation map. Our results suggest that recording sites with both attractive and repulsive shifts following adaptation may be located in close proximity to iso-orientation domain boundaries or pinwheel centers. Indeed, those regions have a more diverse orientation distribution of local inputs that could account for the three properties above. On the other hand, sites with all cells shifting their preferred orientation in the same direction could be located within iso-orientation domains. Our results suggest that the direction and amplitude of orientation preference shifts in V1 depend on location within the orientation map. This anisotropy of adaptation-induced plasticity, comparable to that of the visual cortex itself, could have important implications for our understanding of visual adaptation at the psychophysical level.
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影响因子：
25
作者：
Mariño, J;Schummers, J;Sur, M
通讯作者：
Sur, M
DOI：
10.1073/pnas.022638499
发表时间：
2002-02-05
影响因子：
11.1
作者：
Mazer, JA;Vinje, WE;Gallant, JL
通讯作者：
Gallant, JL
影响因子：
56.9
作者：
MAFFEI, L;FIORENTINI, A;BISTI, S
通讯作者：
BISTI, S
影响因子：
3.3
作者：
Ghisovan, N.;Nemri, A.;Molotchnikoff, S.
通讯作者：
Molotchnikoff, S.
影响因子：
--
作者：
Gibson, JJ;Radner, M
通讯作者：
Radner, M