Stress enhances gait disturbance induced by lumbar disc degeneration in rat
Stress enhances gait disturbance induced by lumbar disc degeneration in rat
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DOI：
10.1007/s00586-017-5243-z
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发表时间：
2018-01-01
影响因子：
2.8
通讯作者：
Naiki, Mitsuru
中科院分区：
文献类型：
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作者：
Fukui, Daisuke;Kawakami, Mamoru;Naiki, Mitsuru
虽然心理因素被认为是压力相关的背痛的主要原因，但还没有在动物模型中研究压力和腰痛之间的关系。本研究采用CatWalk法观察特异性温度节律变化（SART）应激对腰椎小关节切除术后下腰痛大鼠步态异常的影响，将60只大鼠分为对照组、假手术组和实验组。每组又分为非SART应激组和SART应激组。术后7周，采用von Frey试验和CatWalk法评价大鼠的行为学变化，SART应激组大鼠后爪阈值显著低于非SART应激组。在非SART应激条件下，实验组的步态周期、站立时间和平均速度均发生显著变化，但SART应激不仅导致这些参数发生显著变化，而且导致占空比和摆动时间等其他参数发生显著变化，这可能表明SART应激增强了步态障碍。在这个动物模型中，我们首次证明了压力可能是导致腰痛恶化的一个因素。
Although psychological factors are assumed to be the primary cause of stress-related back pain, there have been no studies of the relationships between stress and low back pain in an animal model. The purpose of this study was to examine the influence of specific alternation of rhythm in temperature (SART) stress on gait abnormality using the CatWalk method in a rat model of low back pain caused by lumbar facetectomy.Sixty rats were divided into three groups: the control, sham and experimental groups. Each group was then divided into non-SART stress and SART stress subgroups. We evaluated the behavioral changes 7 weeks postoperatively using the von Frey test and the CatWalk method.Threshold values for the hind paw in the SART stress subgroups were significantly lower than those in the non-SART stress subgroups. In the experimental group, significant changes by CatWalk in step cycle, stand time and average speed were observed under non-SART stress conditions, but SART stress resulted in additional significant changes in not only these parameters, but in other parameters including the duty cycle and swing time, compared with those in the control and sham groups.The demonstration by CatWalk analysis may indicate that SART stress enhanced gait disturbance. In this animal model, we demonstrated for the first time that stress may be a factor involved in worsening of low back pain.