INDUCTION OF ANTERIOR CHAMBER-ASSOCIATED IMMUNE DEVIATION REQUIRES AN INTACT, FUNCTIONAL SPLEEN
INDUCTION OF ANTERIOR CHAMBER-ASSOCIATED IMMUNE DEVIATION REQUIRES AN INTACT, FUNCTIONAL SPLEEN
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DOI：
10.1084/jem.153.5.1058
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发表时间：
1981-01-01
影响因子：
15.3
通讯作者：
NIEDERKORN, JY
中科院分区：
文献类型：
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作者：
STREILEIN, JW;NIEDERKORN, JY
前房相关免疫偏离（ACAID）在前房内接种[小鼠肥大细胞瘤] P815细胞的BALB/c小鼠中以以下3种方式表达：眼内肿瘤的进行性生长，皮下注射P815细胞的短暂生长，DBA/2同种异体皮肤移植物的接受时间延长。脾脏在ACAID的发生发展中起着至关重要的作用。带有前房内P815肿瘤的脾切除动物以加速的方式排斥DBA/2皮肤移植物。在前房内接种P815细胞后的前10天内需要一个功能正常的脾脏，但此后则不需要。重建实验表明，脾脏支持诱导ACAID的能力部分取决于其组成淋巴细胞，但也取决于基质成分或独特的结构安排，只能用脾碎片恢复。可以设计使用适当时机的脾切除术和特异性免疫的治疗方案，以诱导携带眼内肿瘤的宿主产生足够强烈的免疫应答，以破坏眼内的肿瘤，并足够精确地保护眼的功能和解剖完整性。
Anterior chamber-associated immune deviation (ACAID) expresses itself in BALB/c mice inoculated intracamerally with [mouse mastocytoma] P815 cells in the following 3 ways: progressive growth of the tumor within the eye, transient growth of P815 cells injected s.c. and prolonged acceptance of DBA/2 skin allografts. The spleen played a crucial role in the development of ACAID. Splenectomized animals bearing intracameral P815 tumors reject DBA/2 skin grafts in an accelerated manner. A functioning spleen was required during the first 10 days after intracameral inoculation of P815 cells, but not thereafter. Reconstitution experiments revealed that the spleen''s ability to support the induction of ACAID depends partly upon its constituent lymphoid cells, but also upon a stromal component or a unique architectural arrangement that can only be restored with splenic fragments. Therapeutic protocols using appropriately timed splenectomy and specific immunization probably can be devised to induce hosts bearing intraocular tumors to mount an immune response sufficiently vigorous to destroy the tumor within the eye and sufficiently precise to preserve the functional and anatomic integrity of the eye.